复方阿嗪米特肠溶片联合兰索拉唑肠溶片和多潘立酮片用于腹腔镜胆囊切除术后胆结石患者的临床研究  

Clinical trial of compound azinmide enteric-coated tablets combined with lansoprazole enteric coated tablets and domperidone tablets in the treatment of patients with gallstones after laparoscopic cholecystectomy

作　　者：许国梁[1] 汪东树[1] 张国平[1] 沈剑涛 XU Guo-liang;WANG Dong-shu;ZHANG Guo-ping;SHEN Jian-tao(Department of General Surgery,Anqing Municipal Hospital,Anqing 246003,Anhui Province,China)

机构地区：[1]安庆市立医院普外科,安徽安庆246003

出　　处：《中国临床药理学杂志》2020年第11期1464-1466,共3页The Chinese Journal of Clinical Pharmacology

基　　金：安徽省自然科学基金资助项目(1608085J07)。

摘　　要：目的观察复方阿嗪米特肠溶片联合兰索拉唑肠溶片和多潘立酮片用于腹腔镜胆囊切除术后胆结石患者的临床疗效及安全性。方法将81例腹腔镜胆囊切除术后胆结石患者随机分为对照组39例和试验组42例。2组患者均进行腹腔镜胆囊切除术。对照组术后给予兰索拉唑肠溶片每次15 mg,bid,口服+多潘立酮片每次10 mg,tid,口服;试验组在对照组治疗的基础上,给予复方阿嗪米特肠溶片每次2片,tid,口服。2组患者均治疗3个月。比较2组患者的临床疗效和药物不良反应的发生情况。结果治疗后,试验组和对照组的总有效率分别为95.24%(40例/42例)和71.79%(28例/39例),差异有统计学意义(P<0.05)。试验组发生的药物不良反应有恶心、发热和乏力,对照组发生的药物不良反应有恶心、发热、头晕和乏力。试验组和对照组的总药物不良反应发生率分别为7.14%和15.38%,差异无统计学意义(P>0.05)。结论复方阿嗪米特肠溶片联合兰索拉唑肠溶片和多潘立酮片用于腹腔镜胆囊切除术后胆结石患者的临床疗效确切,且不增加药物不良反应的发生率。Objective To observe the clinical efficacy and safety of compound azinmide enteric-coated tablets combined with lansoprazole enteric coated tablets and domperidone tablets in the treatment of patients with gallstones after laparoscopic cholecystectomy.Methods A total of 81 patients with cholelithiasis after laparoscopic cholecystectomy were randomly divided into control group(n=39 cases)and treatment group(n=42 cases).Laparoscopic cholecystectomy was performed in two groups.Control group was given lansoprazole enteric coated tablets 15 mg per time,bid,orally+domperidone tablets 10 mg per time,tid,orally.Treatment group received compound azinmide enteric-coated tablets 2 tablets per time,tid,orally,on the basis of control group.Two groups were treated for 3 months.The clinical efficacy and adverse drug reactions were compared between two groups.Results After treatment,the total effective rates of treatment and control groups were 95.24%(40cases/42 cases)and 71.79%(28 cases/39 cases)with significant difference(P<0.05).The adverse drug reactions in the treatment group were nausea,fever and fatigue,while those in the control group were nausea,fever,dizziness and fatigue.The incidences of total adverse drug reactions in the treatment and control groups were 7.14%and 15.38%without significant difference(P>0.05).Conclusion Compound azinmide enteric-coated tablets combined with lansoprazole enteric coated tablets and domperidone tablets have a definitive clinical efficacy in the treatment of patients with gallstones after laparoscopic cholecystectomy,without increasing the incidence of adverse drug reactions.

关 键 词：复方阿嗪米特肠溶片 兰索拉唑肠溶片 多潘立酮片 腹腔镜胆囊切除术 胆结石 安全性评价 

分 类 号：R97[医药卫生—药品]