细颗粒物导致细胞凋亡的机制及对哮喘致病的影响  

Mechanism of cell apoptosis caused by fine particulate matter and its effect on pathogenesis of asthma

作　　者：赵云霞[1] 张会然[2] 关继涛[2] 阎锡新[2] 于风雪[3] Zhao Yunxia;Zhang Huiran;Guan Jitao;Yan Xixin;Yu Fengxue(The First Department of Respiratory Medicine,The Third Hospital of Hebei Medical University;The First Department of Respiratory and Critical Care Medicine,The Second Hospital of Hebei Medical University;Department of Central Laboratory,The Second Hospital of Hebei Medical University)

机构地区：[1]河北医科大学第三医院呼吸一科,石家庄050051 [2]河北医科大学第二医院呼吸与危重症医学一科,石家庄050051 [3]河北医科大学第二医院中心实验室,石家庄050051

出　　处：《重庆医科大学学报》2020年第6期708-713,共6页Journal of Chongqing Medical University

基　　金：国家自然科学基金资助项目(编号:81770020)。

摘　　要：细颗粒物(fine particulate matter,PM2.5)导致人类呼吸系统疾病发病率和死亡率均有明显上升,尤其是对支气管哮喘(简称哮喘)的影响已经引起越来越广泛的关注和研究。本文就PM2.5对人群哮喘的临床影响、成分组成、诱导细胞凋亡的机制及PM2.5诱导凋亡在哮喘致病中的作用作一综述。The morbidity and mortality of respiratory diseases caused by fine particulate matter(PM2.5)in human beings have increased significantly,and its effect on bronchial asthma(hereinafter asthma)has particularly attracted more and more attention and research.This article reviewed the clinical effect of PM2.5 on asthma,the composition of PM2.5,the mechanism of PM2.5-induced apoptosis and the role of PM2.5-induced apoptosis in the pathogenesis of asthma.

关 键 词：细颗粒物 哮喘 凋亡 

分 类 号：R562.2[医药卫生—呼吸系统]