FeNO检测在儿童哮喘治疗中的临床价值研究  

Clinical value of FeNO detection on treatment of childhood asthma

作　　者：莫运波[1] 周刚 刘玉姣 谭汉梅[1] 何晓玲 彭哲[1] 余洁[1] Mo Yunbo;Zhou Gang;Liu Yujiao;Tan Hanmei;He Xiaoling;Peng Zhe;Yu Jie(Department of Children's Respiratory,Chongqing Three Gorges Central Hospital)

机构地区：[1]重庆三峡中心医院儿童呼吸病区,重庆404000

出　　处：《重庆医科大学学报》2020年第6期795-798,共4页Journal of Chongqing Medical University

摘　　要：目的:探究呼出气一氧化氮(fractional exhaled nitric oxide,FeNO)检测在儿童支气管哮喘(以下简称哮喘)吸入性糖皮质激素(inhaled corticosteroids,ICS)剂量调整中的应用价值。方法:选取153例初次诊断或既往虽被诊断哮喘但尚未按哮喘规范治疗的患儿作为研究对象,采用随机队列研究方法将哮喘患儿随机分为FeNO组和对照组,在入组后3、6、9、12个月时入院随访,对照组根据哮喘控制水平、肺功能检测结果调整ICS剂量,FeNO组在此基础上联合FeNO检测结果进行调整。随访1年后,观察2组间哮喘控制情况和ICS用药剂量。结果:入组时2组间临床特征无差异。随访1年后FeNO组哮喘患儿ICS使用剂量明显低于对照组[13.85(7.45~20.23)vs.28.07(19.38~36.76),P=0.008],且FeNO组停药患儿数量多于对照组(P=0.014)。结论:FeNO作为一种无创的检验手段,可以反映气道炎症情况,可作为指导哮喘儿童ICS剂量的监测指标之一。Objective:To explore the value of fractional exhaled nitric oxide(FeNO)detection on the adjustment of inhaled corticosteroid(ICS)dose in children with bronchial asthma.Methods:A total of 153 children who was diagnosed with asthma for the first time or once was diagnosed with asthma but without standard treatment were included as study objects and were randomly allocated into FeNO group and control group via random cohort study method.Besides,the FeNO group is adjusted according to the FeNO results.Admission follow-up was given after enrollment of 3,6,9 and 12 months.In the control group,the dose of ICS was adjusted in accordance with the asthma control level and lung function result;in the FeNO group,it was adjusted in accordance with those combined with FeNO results.After the follow-up of one year,asthma control level and ICS dose were obeserved.Results:There were no differences in clinical features between two groups at the time of enrollment.After follow-up of one year,the dose of ICS in the FeNO group was significantly lower than that in the control group[13.85(7.458-20.23)vs.28.07(19.38-36.76),P=0.008],and the number of children withdrew ICS in the FeNO group was higher than that in the control group(P=0.014).Conclusion:FeNO,as a non-invasive detecting way,can reflect airway inflammation and act as one of the indicators for adjusting the dose of ICS in children with asthma.

关 键 词：支气管哮喘 呼出气一氧化氮 肺功能 吸入性糖皮质激素 

分 类 号：R720.5[医药卫生—儿科]