胎球蛋白A与慢性肾脏病血管钙化的研究进展  

Progress in Study of Fetuin A Associated with Vascular Calcification in Chronic Kidney Disease

作　　者：束金莲[1] 李贺[1] 孙本贵[1] SHU Jinlian;LI He;SUN Bengui(Department of Nephrology,the Second People′s Hospital of Hefei,Hefei 230011,China)

机构地区：[1]合肥市第二人民医院肾内科,合肥230011

出　　处：《医学综述》2020年第13期2554-2558,共5页Medical Recapitulate

摘　　要：胎球蛋白A是一种具有抗钙化活性的糖蛋白,广泛存在于血液循环中。血管钙化是慢性肾脏病(CKD)患者并发心血管疾病的主要影响因素,其中胎球蛋白A钙化抑制因子在血管钙化的主动调节过程中发挥重要作用。虽然CKD患者体内血管钙化与胎球蛋白A之间具有相关性,但由于在CKD透析与非透析患者中研究结果不一致,故目前尚未达成共识,且胎球蛋白A抑制CKD患者体内血管钙化的具体机制尚不明确。CKD血管钙化可能是微炎症反应、胎球蛋白A竞争抑制、细胞凋亡、内皮细胞损伤等多因素作用的结果。Fetuin A is a anti-calcification glycoprotein,widely found in the blood circulation.Vascular calcification commonly exists in chronic kidney disease(CKD)patients,which is a major influencing factor of the complicated cardiovascular diseases,and fetuin A calcification inhibitors play an important role in the active regulation process of vascular calcification.There is a correlation between vascular calcification and fetuin A in patients with CKD,but the results of dialysis and non-dialysis CKD patients are inconsistent,where no consensus has been reached,and the specific mechanism of fetuin A inhibition of vascular calcification in patients with CKD is still unclear,which is believed to be the result of multiple factors including microinflammation,fetuin A competition inhibition,cell apoptosis,and endothelial cell injury etc.

关 键 词：慢性肾脏病 胎球蛋白A 血管钙化 

分 类 号：R692[医药卫生—泌尿科学]