黛茶生物黏附贴片制备工艺研究  

Study on preparation technology for buccoadhesive compacts of Daicha(Indigo Naturalis and Catechu)

作　　者：宋玉桂 付英杰[1] SONG Yugui;FU Yingjie(College of Pharmacy,Jining Medical University,Rizhao 276826,China)

机构地区：[1]济宁医学院药学院,日照276826

出　　处：《济宁医学院学报》2020年第3期194-197,共4页Journal of Jining Medical University

基　　金：国家大学生创新训练计划项目(201610443068);济宁医学院大学生创新训练计划项目(cx2015058)。

摘　　要：目的 选择治疗口腔溃疡临床疗效较好的宋文山临床验方,研制生物黏附制剂黛茶贴片。方法采用粉末直接压片工艺,以片剂硬度、含量、释药曲线等为指标,筛选优化黛茶贴片的处方及制备工艺。结果生物黏附材料优选为阿拉伯胶,最大载药量的配比为1∶3,采用粉末直压工艺压片,片重150mg。结论 本制备工艺的优化研究,改变了传统用药剂型,改善了传统用药的不足之处。Objective Song Wenshan’s clinical prescription with good curative effect in the treatment of aphthous ulcers was selected to develop the buccoadhesive compacts of Daicha.Methods The powder direct tableting process was used to select and optimize the formula and preparation process by using tablet hardness,content,drug release curve as indicators.Results The raw adhesive material was preferably gum arabic.The maximum drug loading ratio was 1:3.And the tablet was compressed by a powder direct pressure process and the tablet weight was 150 mg.Conclusion The optimization research of the preparation process has changed the traditional medicine type and improved the deficiency of the traditional medicine.

关 键 词：生物黏附 黛茶贴片 制备工艺 

分 类 号：R283.6[医药卫生—中药学]