SIRT4的酶活性及其生物学功能  

An overview of SIRT4 enzyme activities and its related biological functions

作　　者：王常明 朱育焱[1] 孔垂泽[1] WANG Chang-ming;ZHU Yu-yan;KONG Chui-ze(Department of Urology,the First Affiliated Hospital of China Medical University,Shenyang 110001,China)

机构地区：[1]中国医科大学附属第一医院泌尿外科,辽宁沈阳110001

出　　处：《解剖科学进展》2020年第3期357-360,共4页Progress of Anatomical Sciences

基　　金：国家自然科学基金(81472403,81472404,81672523)。

摘　　要：哺乳动物沉默信息调节因子2(silent information regulator two,SIRT)家族有7名成员,SIRT1-7,它们的分子结构具有高度的保守性,每个分子都具有一个由275个氨基酸组成的催化中心,通过对下游目标蛋白进行翻译后修饰,参与机体内许多重要的生理过程,但是它们在细胞内的分布,酶活性以及生物学功能各不相同。其中,位于线粒体中SIRT4已被证明在胰岛素分泌,脂肪酸代谢,氨基酸代谢,ATP稳态等过程中发挥着重要的作用,SIRT4还具有肿瘤抑制的功能。The mammalian silent information regulator two(SIRT)family contains seven members,SIRT1-7,whose molecular structure is highly fidelity,and each molecule has a catalytic center composed of 275 amino acids.They participate in many important biological processes in the cell via post-translational modification of downstream target proteins,but their distribution in cells,enzyme activities and biological functions are different.Among them,Mitochondrial SIRT4 has been shown to play an important role in insulin secretion,fatty acid oxidation,amino acid metabolism,ATP homeostasis,SIRT4 has tumor suppressor function.

关 键 词：SIRT4 催化活性 ADP GDH 酰胺酶 细胞分泌 线粒体 胰岛素分泌 生物学功能 酶活性 

分 类 号：Q814.9[生物学—生物工程]