老药新用:氯喹体内外抗病毒研究进展  

New use of an old drug:advances in antiviral effect of chloroquine in vivo and in vitro

作　　者：王晖 童隆财 李荣 吴广[1] 周玉生 WANG Hui;TONG Long-cai;LI Rong;WU Guang;ZHOU Yu-sheng(The Second Affiliated Hospital,University of South China,Hengyang 421001,China;Institute of Pharmaceutical Pharmacology,University of South China,Hengyang 421001,China;The Affiliated Nanhua Hospital,University of South China,Hengyang 421001,China)

机构地区：[1]南华大学附属第二医院,湖南衡阳421001 [2]南华大学药物药理研究所,湖南衡阳421001 [3]南华大学附属南华医院,湖南衡阳421001

出　　处：《药学学报》2020年第6期1125-1136,共12页Acta Pharmaceutica Sinica

基　　金：湖南省卫健委重点资助项目(20201914);湖南省教育厅资助项目(17C1401);衡阳市科技计划项目(202010031549);南华大学医院管理研究与改革资助项目(2019YYGL02);南华大学资助项目(nk2020207)。

摘　　要：氯喹是1934年德国学者合成的一种奎宁衍生物。除了具有抗疟疾、治疗系统性红斑狼疮和免疫调节作用外,氯喹还显示具有广谱的抗病毒作用,临床试验也证实其对艾滋病有较好的疗效。2019年出现了许多新型冠状病毒(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2)感染的患者,初步的临床试验显示,氯喹对SARS-CoV-2感染患者有明显的疗效。作者通过总结氯喹对不同病毒的作用,阐述其作用机制,分析比较其在体内外作用的效果。氯喹抗病毒的体内与体外结果不一致,可能与动物模型、氯喹的剂量及体内分布、临床研究设计有关。Chloroquine is a quinine derivative which is synthesized by German scholars in 1934.In addition to its anti-malaria,treatment of systemic lupus erythematosus and immunomodulatory effects,chloroquine is also found valuable in broad-spectrum antiviral treatment.Clinical trials have confirmed that chloroquine has a good effect on acquired immunodeficiency syndrome.In 2019,there were many patients infected with novel coronavirus(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2).Preliminary clinical trials showed that chloroquine had obvious curative effect on patients with SARS-CoV-2.We summarize the effects of chloroquine to different viruses,explain its mechanism,and compare the results of its experiments in vitro and in vivo.The antiviral effect of chloroquine in vivo and in vitro are not consistent,which may be related to the model of animal,dosage and distribution of chloroquine in vivo,and the design of clinical research.

关 键 词：氯喹 抗病毒药物 细胞增殖 动物实验 临床试验 

分 类 号：R965[医药卫生—药理学]