肠道派氏结M细胞在淋巴传递中的生物功能及靶向载体研究进展  

Progresses on biological function and targeting vehicles of intestinal Peyer’s patches M cells in lymphatic transmission

作　　者：杜瑶瑶 王冰[1,2] 张宁 DU Yao-yao;WANG Bing;ZHANG Ning(School of Pharmacy,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Center for Pharmaceutics Research,Shanghai Institute of Materia Medica Chinese,Academy of Sciences,Shanghai 201203,China;Experiment Center for Science and Technology,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学中药学院,上海201203 [2]中国科学院上海药物研究所制剂研究中心,上海201203 [3]上海中医药大学科技实验中心,上海201203

出　　处：《药学学报》2020年第6期1166-1174,共9页Acta Pharmaceutica Sinica

基　　金：上海市“科技创新行动计划”生物医药领域科技支撑项目(17401902300)。

摘　　要：肠道派氏结(Peyer’s patches,PPs)是诱导黏膜免疫应答的重要部位,M细胞(microfold cells,M cells)作为PPs中一种特化的上皮细胞,具有摄取抗原的独特能力,能够通过将抗原传递给PPs中的树突状细胞(dendritic cells,DCs)来促进全身免疫应答。选择合适的递药载体并利用特异性配体对载体进行修饰,可以将药物及生物活性物质靶向递送至M细胞以发挥治疗肠道免疫相关疾病的作用。本文综述了近20年相关文献,对靶向M细胞的配体、载体种类、材料性质及影响M细胞摄取的主要因素进行了归纳与分析,以期为研究PPs M细胞靶向递药策略提供可资借鉴的构建思路和实验方法。Intestinal Peyer’s patches(PPs)are important sites to induce mucosal immunity response.As a kind of specialized epithelial cells in PPs,microfold cells(M cells)have a unique ability to take up antigens and can promote systemic immune response by transferring antigens to dendritic cells(DCs)in PPs.Selecting a suitable drug delivery vehicle and modifying the vehicle with a specific ligand can target drugs and bioactive substances to M cells to exert a therapeutic effect on intestinal immune-related diseases.This paper reviews the relevant literatures in the past 20 years,and summarizes and analyzes the ligands,types of vehicles,material properties that target M cells and main factors affecting the uptake of M cells,in order to provide construction ideas and experimental methods that can be worthy of reference for the study of PPs M cells-targeting drug delivery strategies.

关 键 词：黏膜免疫 派氏结 M细胞 配体 载体 

分 类 号：R943[医药卫生—药剂学]