不同糖耐量异常患者胰岛素抵抗与甲状腺结节的相关性研究  

Correlation between insulin resistance and thyroid nodules in patients with different glucose tolerance

作　　者：王夏叶[1] 钱小情[1] 丁世玲[1] WANG Xia-ye;QIAN Xiao-qing;DING Shi-ling(Lishui Hospital of Traditional Chinese Medicine,Lishui 323000,China)

机构地区：[1]丽水市中医院,浙江323000

出　　处：《中国地方病防治》2020年第2期117-119,共3页Chinese Journal of Control of Endemic Diseases

摘　　要：目的探讨在不同糖耐量异常患者中胰岛素抵抗与甲状腺结节的相关性。方法选取100例糖调节受损患者及110例2型糖尿病(T2DM)患者,另选取同期健康体检者106例为正常对照组,比较各组甲状腺结节检出率的差异,同时根据有无胰岛素抵抗,将纳入研究的人员分为胰岛素抵抗组和无胰岛素抵抗组,比较两组之间甲状腺结节检出率的差异,采用Logistic回归分析胰岛素抵抗与甲状腺结节的关系。结果 T2DM组收缩压、舒张压、BMI、TC、LDL-C、FBG、FINS、HOMA-IR、Hb A1c、TSH和甲状腺结节检出率均高于糖调节受损组和正常对照组,且差异均有统计学意义(P <0.05);糖调节受损组TC、LDL-C、FBG、FINS、HOMA-IR、Hb A1c和甲状腺结节检出率均高于正常对照组,且差异均有统计学意义(P<0.05);Logistic回归分析结果提示,HOMA-IR是甲状腺结节发生的独立危险因素(OR=2.689,95%CI 1.515~4.006,P=0.011);胰岛素抵抗组甲状腺结节检出率明显高于无胰岛素抵抗组(68.21%vs39.39%,P<0.05)。结论在不同糖耐量异常患者中,胰岛素抵抗是甲状腺结节发生的独立危险因素。Objective To investigate the correlation between insulin resistance and thyroid nodules in patients with different glucose tolerance.Methods 100 patients with impaired glucose regulation( IGR),110 patients with type 2 diabetes( T2 DM) and106 healthy people as the control group were enrolled in our study. The differences in the detection rate of thyroid nodules were compared among three groups.All subjects were divided into the insulin resistance group and no insulin resistance group according to the presence or absence of insulin resistance and the detection rate of thyroid nodules were compared between the two groups.The correlation between insulin resistance and thyroid nodules were analyzed by logistic regression.Results Compared with the IGR and the control group,patients with T2 DM had higher systolic blood pressure,diastolic blood pressure,BMI,TC,LDL-C,FBG,FINS,HOMA-IR,HbA1 c,TSH and the detection rate of thyroid nodules( P < 0.05). Patients with IGR had TC,LDL-C,FBG,FINS,HOMA-IR,HbA1 c and the detection rate of thyroid nodule of patients with IGR were higher than those of the control group( P<0.05).Logistic regression analysis showed that HOMA-IR was an independent risk factor for thyroid nodules( OR = 2.689,95% CI 1.515 ~ 4. 006,P = 0. 011). The detection rate of thyroid nodules was significantly higher in the insulin resistance group than in the no insulin resistance group( 68.21% vs 39.39%,P<0.05).Conclusion Insulin resistance was an independent risk factor for thyroid nodules in patients with different glucose tolerance.

关 键 词：不同糖耐量异常 甲状腺结节 胰岛素抵抗 

分 类 号：R581.3[医药卫生—内分泌]