黄芪桂枝五物汤预防奥沙利铂所致周围神经毒性疗效及安全性的系统评价  

Systematic evaluation of efficacy and safety of Huangqi Guizhi Wuwu Decoction for preventing oxaliplatin-induced peripheral neurotoxicity

作　　者：王慧 魏晓晨[2] 朱立勤 王春革[2] 邓琦[2] 李新[2] Wang Hui;Wei Xiaochen;Zhu Liqin;Wang Chunge;Deng Qi;Li Xin(Department of Pharmacy,Nankai University Affiliated Hospital(Tianjin Fourth Hospital),Tianjin 300222,China;Department of Pharmacy,Tianjin First Central Hospital,Tianjin 300192,China)

机构地区：[1]南开大学附属医院(天津市第四医院)药剂科,300222 [2]天津市第一中心医院药剂科,300192

出　　处：《国际生物医学工程杂志》2020年第1期24-30,共7页International Journal of Biomedical Engineering

基　　金：天津市卫生局科研课题(2014KY09)。

摘　　要：目的系统评价黄芪桂枝五物汤对奥沙利铂所致周围神经毒性(OIPN)的预防作用。方法计算机检索PubMed、ScienceDirect、EMbase、VIP、CNKI以及万方数据库,检索时间从建库到2019年7月,纳入黄芪桂枝五物汤预防OIPN的随机对照试验(RCTs),并进行质量评价和资料提取,采用RevMan5.3软件进行Meta分析。结果共纳入15个RCT,共849例患者。Meta分析结果表明:黄芪桂枝五物汤与空白对照组在OIPN总发生率[RR=0.57,95%CI(0.40,0.81),P=0.002]及严重OIPN发生率[RR=0.35,95%CI(0.25,0.48),P<0.00001]方面差异有统计学意义(P<0.05),但在疾病控制率方面差异无统计学意义(P>0.05);黄芪桂枝五物汤与甲钴胺在OIPN总发生率[RR=0.51,95%CI(0.39,0.66),P<0.00001]及严重OIPN发生率[RR=0.37,95%CI(0.19,0.70),P=0.002]方面差异均有统计学意义(均P<0.05)。结论黄芪桂枝五物汤能安全有效地预防OIPN的发生,效果优于甲钴胺,且不影响化疗疗效,可在临床中广泛使用。Objective To evaluate the efficacy and safety of Huangqi Guizhi Wuwu Decoction for preventing oxaliplatin-induced peripheral neurotoxicity(OIPN).Methods PubMed,ScienceDirect,EMbase,VIP,CNKI and WanFang Data were searched to collect the randomized controlled trials(RCTs)of Huangqi Guizhi Wuwu Decoction for OIPN from the date of establishment until July 2019.Two reviewers independently evaluated the quality of literature and extracted data.RevMan5.3 software was used for Meta-analysis.Results Fifteen RCTs(849 patients)were included.The results of Meta-analyses showed statistically significant differences in favor of Huangqi Guizhi Wuwu Decoction group compared with control group for all incidence of OIPN[RR=0.57,95%CI(0.40,0.81),P=0.002]and incidence of serious OIPN[RR=0.35,95%CI(0.25,0.48),P<0.00001].No differences were observed in disease control rates between two groups.There was statistically significant differences between Huangqi Guizhi Wuwu Decoction group and mecobalamine group for all incidence of OIPN[RR=0.51,95%CI(0.39,0.66),P<0.00001]and incidence of serious OIPN[RR=0.37,95%CI(0.19,0.70),P=0.002].Conclusions Huangqi Guizhi Wuwu Decoction is more safety and effective than mecobalamine on the prevention of OIPN and did not affect the efficacy of chemotherapy.So Huangqi Guzhi Wuwu decoction can be widely extended to clinical applications.

关 键 词：黄芪桂枝五物汤 奥沙利铂 周围神经毒性 预防 系统评价 

分 类 号：R273[医药卫生—中西医结合]