七叶皂苷钠致肾功能损害文献分析  

Literature analysis of renal impairment related to sodium aescinate

作　　者：李燕华[1] 李仲昆 丁莉[1] 夏洪颖[1] 赵方允[1] 梁月琴[1] Li Yanhua;Li Zhongkun;DING Li(Department of Pharmacy,Yan'an Hospital Affiliated to Kunming Medical University,Yunnan Province,Kunming 650051,China)

机构地区：[1]昆明医科大学附属延安医院药学部,昆明市650051

出　　处：《临床合理用药杂志》2020年第16期22-24,共3页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的分析七叶皂苷钠致肾功能损害的临床特点,为临床安全用药提供参考。方法通过检索中国学术期刊全文数据库(CNKI)、万方数据库(WANFANG)、维普中文科技期刊数据库(VIP)和Medline、Pubmed、Springer数据库,收集七叶皂苷钠相关肾功能损害案例报道,并对患者性别、年龄、肾功能损害发生时间、临床表现、治疗及预后等进行统计分析。结果七叶皂苷钠致肾功能损害患者6例,主要见于药物超量和疗程较长者,大部分发生于用药后3~14 d,病情后果较严重。结论七叶皂苷钠单独或合并使用均有可能导致肾损伤,尤其是在超量使用、疗程较长(> 3 d)时更容易发生,故在使用应加强肝肾功能检查及用药监护,早期发现其不良反应并给予对症治疗。Objective To analyze the clinical characteristics of renal impairment caused by sodium aescinate and to provide a reference for safety and rationality of clinical medication.Methods CNKI,WANFANG,VIP,Medline,PubMed and Springer databases were searched for renal impairment induced by sodium aescinate,and the collected informations correlation to sodium aescinate,such as patients;gender,age,the time,clinical manifestation,treatment and prognosis of the kidney damage were analyzed.Results Totally 6 patients with renal impairment after cured by sodium aescinate were collected,mainly happend on the patients who had excess and the long course medication,most of them occurred 3 to 14 days after medication,and the condition was more serious,once happened,the adverse reactions(ADR)were severe.Conclusion Sodium aescinate alone or combined use may lead to kidney damage,especially in excessive use,the long course(>3 d),so the monitoring of the function of liver and kidney and supervision should be strengthened in the course of medication,in order to early detect its adverse reactions and give symptomatic treatment.

关 键 词：七叶皂苷钠 肾功能损害 药品不良反应 文献分析 

分 类 号：R285.6[医药卫生—中药学]