Peptoid-based hierarchically-structured biomimetic nanomaterials: Synthesis, characterization and applications  

基于类肽等级自组装结构仿生纳米材料:合成,表征和应用

作　　者：Jianli Liu Bin Cai Lifeng Cui Chun-Long Chen 刘建丽;蔡彬;崔立峰;陈春龙(School of Materials Science and Engineering,Dongguan University of Technology,Dongguan 523808,China;Physical Sciences Division,Physical and Computational Sciences Directorate,Pacific Northwest National Laboratory,Richland WA 99352,USA)

机构地区：[1]School of Materials Science and Engineering,Dongguan University of Technology,Dongguan 523808,China [2]Physical Sciences Division,Physical and Computational Sciences Directorate,Pacific Northwest National Laboratory,Richland WA 99352,USA

出　　处：《Science China Materials》2020年第7期1099-1112,共14页中国科学（材料科学（英文版）

基　　金：supported by the Startup Research Fund of Dongguan University of Technology(KCYKYQD2017015);the US Department of Energy,Office of Science,Office of Basic Energy Sciences,as part of the Energy Frontier Research Centers program:CSSAS—The Center for the Science of Synthesis Across Scales(DESC0019288)。

摘　　要：Peptoids(or poly-N-substituted glycines)are a promising class of bioinspired sequence-defined polymers due to their highly efficient synthesis,high chemical stability,enzyme hydrolysis resistance,and biocompatibility.By tuning the side chain chemistry of peptoids,it allows for precise control over sequences and achieving a large side-chain diversity.Due to these unique features,in the last several years,many amphiphilic peptoids were designed as highly tunable building blocks for the preparation of biomimetic nanomaterials with well-defined hierarchical structures and desired functionalities.Herein,we provide an overview of the recent achievements in this area by dividing them into the following three aspects.First,mica-and silica-templated peptoid selfassembly are summarized.The presence of inorganic substrates provides the guarantee of investigating their selfassembly mechanisms and interactions between peptoids and substrates using nanoscale characterization techniques,particularly in situ atomic force microscopy(AFM)and AFMbased dynamic force spectroscopy(AFM-DFS).Second,solution-phase self-assembly of peptoids into nanotubes and nanosheets is presented,as well as their self-repair properties.Third,the applications of peptoid-based nanomaterials are outlined,including the construction of catalytic nanomaterials as a template and cytosolic delivery as cargoes.类肽(或N-取代甘氨酸)具有合成效率高、化学稳定性强、抗酶水解及生物相容性好等优点,是一类潜在的可自定义序列的生物仿生聚合物.通过调节类肽的侧链化学,可以精确地控制类肽序列并实现侧链的多样性.基于以上类肽分子独特的优势,在过去的几年里,研究者设计和合成了大量的双亲性类肽作为基本的结构单元,通过自下而上的分子自组装作用构建了结构可控和具有特定功能的仿生纳米材料.本文从以下三个方面综述了我们在类肽自组装领域取得的一些成果.首先,概述了以云母和硅片为无机基底辅助类肽自组装.将原子力显微镜原位成像技术和单分子力谱技术相结合,可实时观察类肽分子在表面的组装过程并直接测定类肽分子与基底间的相互作用,揭示基底表面对类肽自组装的影响.其次,介绍了类肽分子在溶液中自组装成纳米管和具有自修复功能的纳米薄膜.最后,综述了基于类肽自组装纳米材料的应用,包括以类肽自组装纳米材料为催化模板构建纳米仿生催化剂和作为细胞内输送物质的载体等.

关 键 词：PEPTOID self-assembly biomimetic nanomaterial nanoscale characterization assembly mechanism 

分 类 号：TB383.1[一般工业技术—材料科学与工程]