脑血康颗粒对非急性期脑梗死患者颈动脉不稳定斑块的影响及机制研究  

Study on the effect of Naoxuekang granule on carotid artery unstable plaque in patients with non-acute cerebral infarction and its mechanism

作　　者：蒋辉[1] 李辉[1] JIANG Hui;LI Hui(Jiangsu Provincial Hospital of Traditional Chinese Medicine, Nanjing 210000, Jiangsu, China)

机构地区：[1]江苏省中医院,江苏南京210000

出　　处：《现代中西医结合杂志》2020年第19期2057-2061,共5页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：江苏省中医院院级课题(Y17049)。

摘　　要：目的探讨脑血康颗粒对非急性期脑梗死患者颈动脉不稳定斑块的影响及其作用机制。方法纳入2017年1月—2018年3月在江苏省中医院接受治疗且符合要求的非急性期脑梗死合并颈动脉不稳定斑块患者100例,按照随机数字表法分为对照组50例和脑血康组50例。对照组在抗血小板和降脂药物等基础治疗同时给予安慰剂20 g口服,脑血康组在基础治疗以外给予脑血康颗粒20 g口服,均每日2次,疗程均为12个月。采用彩色多普勒超声造影的方法评估2组患者治疗前后颈动脉不稳定斑块等级并记录造影剂增强持续时间,检测2组患者治疗前后血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)水平。结果2组治疗前的Ⅱ/Ⅲ级斑块患者例数、造影剂增强持续时间及血清TC、LDL-C、hs-CRP、IL-6水平比较差异均无统计学意义(P均>0.05)。与治疗前比较,2组治疗12个月后Ⅱ/Ⅲ级斑块患者例数均明显减少,造影剂增强持续时间明显缩短,血清TC、LDL-C、hs-CRP、IL-6水平明显降低,差异均有统计学意义(P均<0.05);与对照组比较,脑血康组的Ⅱ/Ⅲ级斑块患者例数更少,造影剂增强持续时间更短,血清TC、LDL-C、hs-CRP、IL-6水平更低,差异均有统计学意义(P均<0.05)。结论脑血康颗粒可以减少非急性期脑梗死患者颈动脉不稳定斑块内新生血管的数量,改善斑块稳定性,其机制可能与降低血脂及炎症因子hs-CRP、IL-6水平有关。Objective It is to explore the effect and mechanism of Naoxuekang granule on carotid artery unstable plaque in patients with non-acute cerebral infarction.Methods A total of 100 patients with non-acute cerebral infarction and carotid artery unstable plaque who were treated in Jiangsu Provincial Hospital of Traditional Chinese Medicine from January 2017 to March 2018 and met the requirements were divided into control group and Naoxuekang group according to random number table method,50 cases in each group.The control group was given 20g of oral placebo at the same time as basic treatments such as antiplatelet and lipid-lowering drugs,and the Naoxuekang group was given 20g of oral administration of Naoxuekang granules based on the basic treatment,both twice a day for 12 months.Color Doppler ultrasound was used to evaluate the carotid artery unstable plaque classification of all the patients before and after treatment in the two groups and the duration of contrast enhancement was recorded.The levels of serum total cholesterol(TC)and low-density lipoprotein cholesterol(LDL-C),high-sensitivity C-reactive protein(hs-CRP),and interleukin-6(IL-6)before and after treatment were detected in the two groups.Results There was no significant difference in the number of patients with gradeⅡ/Ⅲplaque,duration of contrast enhancement,and the levels of serum TC,LDL-C,hs-CRP,and IL-6 before treatment between the two groups(all P>0.05).Compared with before treatment,the number of patients with gradeⅡ/Ⅲplaques in both groups was significantly reduced after 12 months of treatment,the duration of contrast enhancement was significantly shortened,and the levels of serum TC,LDL-C,hs-CRP,and IL-6 were significantly reduced,the differences were statistically significant(all P<0.05).Compared with the control group,the number of patients with gradeⅡ/Ⅲplaque in the Naoxuekang group was less,the duration of contrast enhancement was shorter,and the levels of serum TC,LDL-C,Hs-CRP,IL-6 were lower,the differences were statistically sign

关 键 词：脑血康颗粒 颈动脉不稳定斑块 超声血管造影 超敏C反应蛋白 白细胞介素-6 

分 类 号：R543.4[医药卫生—心血管疾病]