磁共振动态增强定量参数对克罗恩病病情的评估效果  

Evaluated effect of dynamic enhanced quantitative parameters of magnetic resonance on Crohn's disease

作　　者：刘小玲[1] 阮君[1] 朱敬松[1] LIU Xiao-ling;RUAN Jun;ZHU Jing-song(The Second Affiliated Hospital of Zhengzhou University, Henan, 450014, China)

机构地区：[1]郑州大学第二附属医院放射科,河南郑州450014

出　　处：《淮海医药》2020年第3期245-247,250,共4页Journal of Huaihai Medicine

摘　　要：目的:探究磁共振动态(DCE-MRI)增强定量参数与容积转运常数(K^trans)对克罗恩病(CD)病情的评估效果。方法:选取某院接受治疗的50例克罗恩病患者,对患者分别进行MRI、DCE-MEI扫描和K^trans值测量,同时收集患者的HBI和ADC等各项资料。将50例患者根据HBI水平分为重度活动组10例、轻中度活动组22例和静止组18例,对3组患者的K^trans、ADC进行比较,分析活动期和慢性期CD患者MRI表现及K^trans、ADC、HBI的相关性。结果:3组患者K^trans值、ADC值比较,差异有统计学意义(P<0.05);MRI诊断CD的结果显示:假阳性患者5例,假阴性患者23例,敏感度为66.2%,特异度为84.4%,阳性预测值为90.0%,阴性预测值为54.0%;Spearman和Pearson相关性分析显示:50例CD患者的K^trans与HBI呈现正相关,与ADC呈现负相关,血清ADC与K^trans呈现负相关(P均<0.05)。结论:MRI定量参数K^trans在反应CD活动状态方面有重要作用,具有一定的临床应用价值。Objective:To investigate the effect of dynamic-contrast enhanced magnetic resonance imaging(DCE-MRI)on quantitative assessment of Crohn's disease(CD).Methods:50 patients with CD were selected for routine MRI and DCE-MRI scanning.K^trans was measured and the patients'HBI and C-reactive protein(CRP)and other general information were collected.The 50 patients were divided into a severe activity group(10 cases),a mild to moderate group(22 cases)and a static group(18 cases)according to HBI level.The K^trans and ADC of the three groups were compared to analyze the MRI findings of active and chronic CD patients and correlations between K^trans,ADC and HBI.Results:In comparison of K^trans and ADC between the three groups of patients,the difference was statistically significant(P<0.05).The findings of MRI diagnosed CD indicated that there were 5 false positive cases,23 false negative cases,45 true positive cases and 27 true negative cases.The result of DCE-MRI assessmerit revealed that the sensitivity was 66.2%,the specificity 84.4%,the positive predictive value 90.0%,and the negative predictive value 54.0%.Correlation analysis of Spearman and Pearson showed that K^trans of the 50 CD patients were positively correlated with HBI and negatively correlated with ADC and serum ADC indicated negative correlation with K^trans(P<0.05).Conclusion:Quantitative parameter K^trans of MRI plays an important role in CD activity,and has a high clinical value.

关 键 词：克罗恩病 磁共振动态增加 定量参数 

分 类 号：R445.2[医药卫生—影像医学与核医学] R574[医药卫生—诊断学]