流感病毒感染对小鼠血糖的影响  

Effects of influenza virus infection on blood glucose in mice

作　　者：杨莉莉 孙刚[1] 王笑红[1] 翟志光[1] 孙萌[1] 刘厚涞 王克林[1] YANG Li-li;SUN Gang;WANG Xiao-hong;ZHAI Zhi-guang;SUN Meng;LIU Hou-lai;WANG Ke-lin(Institute of Basic Theory for Chinese Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]中国中医科学院中医基础理论研究所,北京100700

出　　处：《中国中医基础医学杂志》2020年第6期773-776,共4页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：中国中医科学院自主选题(YZ-1703)-疏风宣肺清热解毒法干预肺组织感染的组方与作用特征研究;中国中医科学院自主选题(YZ-1863)-从炎症反应探讨银翘散加减方干预病毒性肺损伤研究。

摘　　要：目的:观察流感病毒感染对小鼠血糖的影响,为深入探讨流感病毒感染导致血糖变化特征及其与流感高危人群的相关性提供实验基础。方法:15~17g BALB/c小鼠随机分为正常组、染毒组每组各10只,雌雄各半,每日固定时间测量血糖、体质量,实验第5天取肺组织并称重。比较2组肺指数、血糖、体质量差值、体质量差异并分析血糖、体质量差值、体质量与肺指数相关性。结果:染毒组小鼠血糖降低,染毒后48 h出现显著性改变,降低幅度为整个实验期间最大;血糖、体质量差值、体质量与肺指数的相关系数依次为r=-0.891,-0.825,-0.820,且P<0.01,即三者与肺指数均呈负相关,而血糖与肺指数相关性最强。结论:感染流感病毒后小鼠血糖明显降低,且血糖与流感病程进展密切相关。Objective:To observe the effect of influenza virus infection on blood sugar in mice for further investigation of the characteristics of blood glucose with influenza,and its correlation with high risk groups.Methods:BALB/c mice of 15-17g were randomly divided into normal group and infected group,10 mice in each group,50% was male and 50% female.Blood sugar and the weight were measured at a fixed time once a day.On the fifth day,the lung of mice were taken and weighed.The differences of lung index,blood sugar,body weight difference and body weight between the groups were compared,and the correlation of blood sugar,body weight difference and lung index was analyzed.Results:1.The blood sugar of mice in infected group decreased significantly after 48 hours infected,the decrease was the largest in the whole experimental period.2.The correlation coefficients of blood sugar,body weight difference,body weight and lung index in mice were r=-0.891,-0.825,-0.820,separately and.The correlation between blood sugar and lung index was the strongest among them.Conclusion:After being infected with influenza virus,the blood sugar of mice decreased significantly,and the blood sugar of mice was closely related to the progress of influenza.

关 键 词：流感病毒感染 血糖 肺指数 

分 类 号：R511.7[医药卫生—内科学]