血清腺苷脱氨酶水平与类风湿关节炎患者疾病活动度的相关性研究  

Study on the Relationship between Serum Adenosine Deaminase Levels and Disease Activity in Patients with Rheumatoid Arthritis

作　　者：陈向波 陈斌[1] 李涛[1] 史世勤 CHEN Xiang-bo;CHEN Bin;LI Tao;SHI Shi-qin(Department of Orthopaedics,the Second Hospital of Yulin,Shaanxi Yulin 719000,China)

机构地区：[1]榆林市第二医院骨一科,陕西榆林719000

出　　处：《现代检验医学杂志》2020年第3期116-119,共4页Journal of Modern Laboratory Medicine

基　　金：陕西省社会发展科技攻关项目(2016SF-187)。

摘　　要：目的探讨血清腺苷脱氨酶(adenosine deaminase,ADA)水平与类风湿关节炎(rheumatoid arthritis,RA)患者疾病活动度的相关性。方法选取86例RA患者为观察组,另选取同期86例体检健康者作为对照组,采用欧洲抗风湿联盟(the European League Against Rheumatism,EULAR)疾病活动指数28(disease activity score28-joint,DAS28)将观察组分为疾病缓解期和疾病活动期(低活动度、中活动度和高活动度)。分析血清中ADA的水平与疾病活动度的相关性。结果与对照组比较,观察组各期患者血清中ADA水平显著升高,且差异具有统计学意义(F=3.407,P<0.05)。血清中ADA水平随着疾病活动度的增加而升高。与高活动度患者比较,疾病缓解期、低活动度、中活动度患者的ADA水平显著降低,且差异具有统计学意义(F=45.034,P<0.05)。相关性分析结果显示,血清中ADA的水平与DAS28呈正相关关系(r=0.486,P<0.001)。ROC曲线分析结果显示血清ADA诊断RA的敏感度、特异度分别为83.7%和86.1%。血清ADA区分RA活动期与缓解期的敏感度、特异度分别为72.9%和85.2%。结论血清ADA水平在RA患者中显著升高,并且与疾病活动程度相关。因此,其可作为评估RA患者疾病活动程度的参考指标。Objective To investigate the correlation between serum adenosine deaminase(ADA)level and disease activity in rheumatoid arthritis(RA)patients.Methods A total of 86 patients with RA in the Second Hospital of Yulin were selected as the observation group,and 86 healthy patients in the same period were selected as the control group.The European rheumatic union disease activity index 28(disease activity score 28-joint,DAS28)was used to divide the observation group into remission period,disease activity period(low activity level,medium activity level and high activity level),and the correlation between serum ADA level and disease activity was analyzed.Results Compared with the control group,the serum level of ADA in each stage of the observation group was significantly increased,and the difference was statistically significant(F=45.034,P<0.05).ADA level in serum increased with the increase of disease activity.Compared with high activity level,ADA level in patients with remission period,low activity level and moderate activity level decreased significantly,and the difference was statistically significant(F=3.407,P<0.05).Correlation analysis showed that ADA level in serum was positively correlated with DAS28(r=0.486,P<0.001)and ROC curve analysis showed that the sensitivity and specificity of serum ADA in diagnosing RA were 83.7%and 86.1%,respectively.The sensitivity and specificity of serum ADA in distinguishing active and remission phases of RA were 72.9%and 85.2%,respectively.Conclusion Serum ADA levels were significantly higher in RA patients and correlated with disease activity.Therefore,it can be used as a reference index to evaluate the degree of disease activity in RA patients.

关 键 词：类风湿关节炎 腺苷脱氨酶 疾病活动度 

分 类 号：R593.22[医药卫生—内科学] R446.112[医药卫生—临床医学]