不同肠外营养使用时间对早产儿胆汁淤积的影响  

Influence of Different Parenteral Nutrition Time on Cholestasis in Preterm Infants

作　　者：袁嫣瑛 蔡俊伟[1] 林淑敏[1] YUAN Yanying;CAI Junwei;LIN Shumin(Department of Pediatrics,Chen Xinghai Hospital,Zhongshan 528400,China)

机构地区：[1]广东省中山市陈星海医院儿科,广东中山528400

出　　处：《临床医学工程》2020年第7期873-874,共2页Clinical Medicine & Engineering

基　　金：广东省中山市卫生局医学科研项目“不同时间肠外营养对早产儿胆汁淤积的影响”(项目编号:2019A020405)。

摘　　要：目的分析不同肠外营养使用时间对早产儿胆汁淤积的影响。方法选取我院2018年1月至2019年7月期间收治的124例早产儿,根据早产儿肠外营养(PN)使用时间不同分为A组(PN≤7 d)、 B组(7 d14 d)。比较三组早产儿肠外营养相关性胆汁淤积(PNAC)发生情况。结果肠外营养使用时间越长,早产儿PNAC发生率越高;C组的PNAC发生率明显高于A组、 B组(P <0.05);C组的DBil、 TBA水平明显高于A组、 B组(P <0.05)。结论早产儿肠外营养使用时间越长、胎龄越小,PNAC发生率越高,因此尽快进行肠内营养能有效降低早产儿PNAC发生率。Objective To analyze the influence of different use time of parenteral nutrition(PN)on cholestasis in preterm infants.Methods 124 preterm infants admitted to our hospital from January 2018 and July 2019 were selected and divided into group A(PN≤7 d),group B(7 d<PN≤14 d)and group C(PN>14 d)according to different use time of parenteral nutrition.The parenteral nutrition associated cholestasis(PNAC)was compare among the three groups.Results The longer the use time of parenteral nutrition,the higher the PNAC incidence in preterm infants.The PNAC incidence of group C was significantly higher than that of groups A and group B(P<0.05).The DBil and TBA levels of group C were significantly higher than those of groups A and group B(P<0.05).Conclusions The longer the use time of parenteral nutrition,and the lower the gestational age,the higher the PNAC incidence.Therefore,enteral nutrition as soon as possible can effectively reduce the PNAC incidence in preterm infants.

关 键 词：早产儿 肠外营养 胆汁淤积 

分 类 号：R722.6[医药卫生—儿科]