产前抑郁与氧化应激的关系及对自发性早产的影响  

Correlation of Antenatal Depression with Oxidative Stress and the Influence on Spontaneous Preterm Birth

作　　者：李伟容[1] 黄秀萍[1] 赵合影 LI Weirong;HUANG Xiuping;ZHAO Heying(The People's Hospital of Boluo County,Huizhou 516100,China)

机构地区：[1]广东省博罗县人民医院,广东惠州516100

出　　处：《临床医学工程》2020年第7期973-974,共2页Clinical Medicine & Engineering

基　　金：2018年惠州市科技计划(医疗卫生)项目(项目编号:2018Y219)。

摘　　要：目的探讨产前抑郁与氧化应激的关系及其对自发性早产的影响。方法收集我院收治的80例孕妇的临床资料,分析影响孕妇发生自发性早产的危险因素。结果 80例孕妇中,17例(21.25%)发生产前抑郁,作为研究组。研究组与对照组的EPDS评分及MDA、 SOD、 CAT、 GSH-Px水平比较有统计学差异(P <0.05)。研究组EPDS评分与MDA水平呈正相关,与SOD、 CAT、 GSH-Px水平呈负相关(P <0.05)。80例孕妇自发性早产发生率为11.25%,其中年龄偏大、有早产史、抑郁症及氧化应激损伤均是孕妇发生自发性早产的危险因素(P <0.05)。结论氧化应激反应与孕妇产前抑郁的发生密切相关,且二者与孕妇年龄、早产史共同成为孕妇发生自发性早产的危险因素,需引起临床工作者的重视。Objective To explore the correlation of antenatal depression with oxidative stress and the influence on spontaneous preterm birth.Methods The clinical data of 80 pregnant women in our hospital were collected,and the risk factors of spontaneous preterm birth were analyzed.Results Among the 80 pregnant women,17 cases(21.25%)had antenatal depression,who were set as study group.Statistical difference was found in the EPDS score and the levels of MDA,SOD,CAT and GSH-Px between the study group and control group(P<0.05).In the study group,EPDS score was positively correlated with MDA level,and was negatively correlated with SOD,CAT and GSH-Px levels(P<0.05).The incidence of spontaneous preterm birth in 80 pregnant women was 11.25%.Older age,preterm birth history,depression and oxidative stress injury were the risk factors of spontaneous preterm birth(P<0.05).Conclusions Oxidative stress is closely correlated with antenatal depression of pregnant women,and both of them,together with the age and preterm birth history become the risk factors of spontaneous preterm birth in pregnant women,which should be paid attention to.

关 键 词：产前抑郁 氧化应激 自发性早产 超氧化物歧化酶 丙二醛 

分 类 号：R714.21[医药卫生—妇产科学]