Effects of prostaglandin E combined with continuous renal replacement therapy on septic acute kidney injury  

作　　者：Li Lei Ming-Jun Wang Sheng Zhang Da-Jun Hu 

机构地区：[1]Department of Nephrology,the Second People's Hospital of Three Gorges University(Yichang Second People's Hospital),Yichang 443000,Hubei Province,China [2]Institute of Nephrology of Integrated Chinese and Western Medicine of Three Gorges University,Yichang 443000,Hubei Province,China

出　　处：《World Journal of Clinical Cases》2020年第13期2738-2748,共11页世界临床病例杂志

摘　　要：BACKGROUND The effects of prostaglandin E(PGE)combined with continuous renal replacement therapy(CRRT)on renal function and inflammatory responses in patients with septic acute kidney injury(SAKI)remain unclear.AIM To investigate the effects of PGE combined with CRRT on urinary augmenter of liver regeneration(ALR),urinary Na+/H+exchanger 3(NHE3),and serum inflammatory cytokines in patients with SAKI.METHODS The clinical data of 114 patients with SAKI admitted to Yichang Second People's Hospital from May 2017 to January 2019 were collected.Fifty-three cases treated by CRRT alone were included in a control group,while the other 61 cases treated with PGE combined with CRRT were included in an experimental group.Their urinary ALR,urinary NHE3,serum inflammatory cytokines,renal function indices,and immune function indices were detected.Changes in disease recovery and the incidence of adverse reactions were observed.The 28-d survival curve was plotted.RESULTS Before treatment,urinary ALR,urinary NHE3,blood urea nitrogen(BUN),serum creatinine(SCr),CD3+T lymphocytes,CD4+T lymphocytes,and CD4+/CD8+T lymphocyte ratio in the control and experimental groups were approximately the same.After treatment,urinary ALR and NHE3 decreased,while BUN,SCr,CD3+T lymphocytes,CD4+T lymphocytes,and CD4+/CD8+T lymphocyte ratio increased in all subjects.Urinary ALR,urinary NHE3,BUN,and SCr in the experimental group were significantly lower than those in the control group,while CD3+T lymphocytes,CD4+T lymphocytes,and CD4+/CD8+T lymphocyte ratio were significantly higher than those in the control group(P<0.05).After treatment,the levels of tumor necrosis factor-α,interleukin-18,and high sensitivity C-reactive protein in the experimental group were significantly lower than those in the control group(P<0.05).The time for urine volume recovery and intensive care unit treatment in the experimental group was significantly shorter than that in the control group(P<0.05),although there was no statistically significant difference in hospital stays bet

关 键 词：Prostaglandin E Continuous renal replacement therapy Septic acute kidney injury Augmenter of liver regeneration Na+/H+exchanger 3 Serum inflammatory cytokines 

分 类 号：R459.7[医药卫生—急诊医学] R692[医药卫生—治疗学]