硫化铜-磷酸钙纳米载体的制备及光热性能研究  

Preparation and photothermal properties of copper sulfidecalcium phosphate nano-carriers

作　　者：田利霞 包志红[1] 郑佳妮[1] 袁悦[1] TIAN Lixia;BAO Zhihong;ZHENG Jiani;YUAN Yue(School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China)

机构地区：[1]沈阳药科大学药学院,辽宁沈阳110016

出　　处：《中国药剂学杂志》2020年第4期203-211,共9页Chinese Journal of Pharmaceutics

摘　　要：目的制备一种硫化铜-磷酸钙纳米载药体系,初步评价其光热性质。方法以聚丙烯酸(Polyacrylic acid,PAA)为稳定剂,氯化铜和硫化钠为原料合成具有光热性质的硫化铜纳米粒(PAA/CuS nanoparticles,PAA/CuS NPs);以聚丙烯酸为模板制备硫化铜-磷酸钙纳米载体(PAA/CuS-CaP nanocarriers,PAA/CuS-CaP NCs);以载体的粒径和Zeta电位作为评价指标,对PAA/CuS-CaP NCs的制备工艺进行优化,并对载体的光热性能进行初步考察。结果PAA/CuS-CaP NCs的最佳处方与工艺为:3.6 mg Ca(OH)2加入到40 mL PAA/CuS NPs水溶液中,搅拌30 min后向其中滴加240 mL异丙醇(水溶液-异丙醇体积比为1︰6),再加入11.60 mg的Na2HPO4·12H2O,室温反应2 h,最终制备出粒径为(146.43±1.6)nm,Zeta电位为-(25.1±0.54)mV的PAA/CuS-CaP NCs。结论该处方工艺简单,构建的PAA/CuS-CaP NCs纳米载体具有优良的光热转换特性,此研究为多功能纳米材料的制备、性能改善和生物医学应用提供了实验基础。Objective To prepare copper sulfide-calcium phosphate nano-carriers,and evaluate the photothermal property.Methods The copper sulfide nanoparticles(PAA/CuS NPs)were synthesized by using polyacrylic acid(PAA)as a stabilizer,copper chloride and sodium sulfide as the raw materials.The copper sulfide-calcium phosphate nano-carriers(PAA/CuS-CaP NCs)were prepared by using PAA as a template.The formulation process of PAA/CuS-CaP NCs was optimized with the particle size and Zeta potential.The photothermal conversion property of PAA/CuS-CaP NCs was investigated.Results The optimal formulation and preparation process of PAA/CuS-CaP NCs were as follows:3.6 mg Ca(OH)2 was added to 40 mL PAA/CuS NPs solution and stirred for 30 min,and 240 mL isopropanol(volume ratio of aqueous solution:isopropanol was 1:6)and 11.60 mg Na2HPO4·12H2O were added,respectively.The reaction solution was stirred at room temperature for 2 h,PAA/CuS-CaP NCs with the particle size of(146.4±1.6)nm and Zeta potential of-(25.1±0.54)mV were obtained.Conclusions The preparation process of PAA/CuS-CaP NCs is simple and PAA/CuS-CaP NCs have excellent photothermal conversion characteristics.This study provides experimental basis for the preparation,performance improvement and biomedical application of multifunctional nanomaterials.

关 键 词：药剂学 纳米载体 模板法 硫化铜-磷酸钙纳米载体 光热转换性能 

分 类 号：R94[医药卫生—药剂学]