晚期早产儿出生时25-(OH)D水平高危因素分析及常规剂量治疗后效果观察  

Analysis of high-risk factors of 25-(OH)D level in late preterm infants at birth and observation of the effect after conventional dose treatment

作　　者：王洪波[1] 王燕玲[1] 贺瑞荣[1] 张秋丽[1] 蔡娟[1] 周建生[1] WANG Hongbo;WANG Yanling;HE Ruirong;ZHANG Qiuli;CAI Juan;ZHOU Jiansheng(Shizuishan First People's Hospital,Shizuishan,Ningxia 753200,China)

机构地区：[1]宁夏回族自治区石嘴山市第一人民医院,753200

出　　处：《重庆医学》2020年第S01期50-52,共3页Chongqing medicine

基　　金：宁夏回族自治区卫生健康委员会科研课题(2019-NW-078)。

摘　　要：目的分析晚期早产儿出生时25羟维生素D[25-(OH)D]水平的相关高危因素,评估晚期早产儿应用常规剂量进行治疗后的疗效。方法选取2017年1月至2019年12月该院新生儿病室住院的晚期早产儿100例,按随机抽样原则分为对照组和研究组,每组50例。对照组补充维生素D 400 U,研究组补充维生素D 800 U。分析早产儿出生时25-(OH)D水平的高危因素,分析和对比两组早产儿疗效。结果冬春季出生、早孕期体重指数大于28 kg/m^2、孕产妇年龄小于30岁为早产儿在出生时维生素D缺乏的相关高危因素,差异有统计学意义(P<0.05)。母亲职业、出生体质量、子痫前期为混杂因素,差异无统计学意义(P>0.05)。两组早产儿补充维生素D之前25-(OH)D水平比较,差异无统计学意义(P>0.05)。两组早产儿补充维生素D之后25-(OH)D水平之间比较,差异有统计学意义(P<0.05)。结论对早产儿补充维生素D可促使其成长。Objective This article mainly analyzes the high-risk factors related to the 25-(OH)D level in late preterm infants at birth,and evaluates the efficacy of conventional preterm infants after treatment with conventional doses.Methods Late preterm infants(number of cases=100cases)who were admitted to the neonatal unit of Shizuishan First People's Hospital from January 2017 to December 2019 were collected,and the patients who participated in the study were grouped according to the principle of random sampling.The control group(Number of cases=50 cases)Vitamin D supplementation(dose=400 U)during treatment.The experimental group(number of cases=50 cases)supplemented with vitamin D(dose=800 U)during treatment.Analysis of high-risk factors,analysis and comparison of treatment effects obtained by preterm infants in experimental group and control group.Results In multivariate analysis,BMI>28 kg/m^2 during the winter and spring,early pregnancy,and maternal age<30 years were the high risk factors for vitamin D deficiency in preterm infants at birth(P<0.05).Maternal occupation,birth weight,and preeclampsia were confounding factors(P>0.05).Before the vitamin D supplementation in the experimental group and the control group,there was no significant difference between the 25-(OH)D levels in the two groups,and there was no difference in the analysis and comparison of the results between the groups(P>0.05).After the vitamin D supplementation in the experimental group and the control group,there was a significant difference between the levels of 25-(OH)D in the two groups,and the analysis of the results in the groups was statistically significant(P>0.05).Conclusion Vitamin D supplementation for preterm infants can promote their growth.

关 键 词：25羟维生素D 维生素D 常规剂量 早产儿 

分 类 号：R72[医药卫生—儿科]