血七胶囊质量标准提高研究  

Improvement of Quality Standard of Xueqi Capsules

作　　者：陆才洋[1] 汪霞 LU Cai-yang;WANG Xia(Hunan Provincial Center for Drug Evaluation,Accreditation and Adverse Drug Reaction Monitoring,Changsha 410013,China;Loudi Institute for Food and Drug Inspection&Testing,Loudi 417000,China)

机构地区：[1]湖南省药品审评认证与不良反应监测中心,湖南长沙410013 [2]娄底市食品药品检验检测所,湖南娄底417000

出　　处：《海峡药学》2020年第6期71-73,共3页Strait Pharmaceutical Journal

摘　　要：目的提高血七胶囊的质量标准。方法采用高效液相色谱法(HPLC),色谱柱为Thermoscientific C 18,流动相为乙腈-水(37∶63),流速1.0mL·min^-1,检测波长278nm,同时测定君药龙血竭中龙血素A、龙血素B的含量。结果龙血素A在16.176~129.408ng范围内线性关系良好(r=1.000),平均加样回收率100.7%,RSD为1.6%;龙血素B在28.598~228.784ng范围内线性关系良好(r=1.000),平均加样回收率101.5%,RSD为1.1%。结论本实验建立的方法具有专属、简便、准确、可重复的特点,增强了血七胶囊的质量可控性,提高了血七胶囊的质量标准。OBJECTIVE To improve the quality standard of Xueqi Capsules.METHODS By HPLC,A Thermoscientific C 18 column was used,with mobile phase of Acetonitrile-water(37∶63).The flow rate was 1.0mL·min^-1 and the detective wavelength was 278nm.Loureirin A、Loureirin B in Dragon′s Blood were simultaneously determined.RESULTS The linear range of Loureirin A was 16.176-129.408ng(r=1.000),the average recovery was 100.7%,with RSD of 1.6%.The linear range of Loureirin B was 28.598-228.784ng(r=1.000),the average recovery was 101.5%,with RSD of 1.1%.CONCLUSION The method is specific,simple,accurate and repeatable.The quality controllability of Xueqi Capsules is enhanced and the quality standard is improved.

关 键 词：龙血素A 龙血素B 血七胶囊 质量标准 

分 类 号：R927[医药卫生—药学]