促红细胞生成素产生细胞与慢性肾脏病贫血及肾纤维化关系的研究进展  

Research progress on the relationship between erythropoietin-producing cells and anemia and fibrosis in chronic kidney disease

作　　者：李菲 魏日胞 Li Fei;Wei Ri-Bao(Department of Clinical Medicine,Medical College of Nankai University,Tianjin 300071,China;Department of Nephrology,the First Medical Center,Chinese PLA General Hospital/Institute of Nephrology of PLA/State Key Laboratory of Kidney Diseases/National Clinical Research Center for Chronic Kidney Disease/Beijing Key Laboratory of Kidney Disease Research,Beijing 100853,China)

机构地区：[1]南开大学医学院临床医学系,天津300071 [2]解放军总医院第一医学中心肾脏病科/全军肾脏病研究所/肾脏疾病国家重点实验室/国家慢性肾病临床医学研究中心/肾脏疾病研究北京市重点实验室,北京100853

出　　处：《解放军医学杂志》2020年第6期680-684,共5页Medical Journal of Chinese People's Liberation Army

基　　金：国家重点研发计划重点专项(2018YFC1704203);国家自然科学基金(81471027,81273968,81072914)。

摘　　要：慢性肾脏病的基本特征是持续性的肾功能下降、细胞外基质的累积以及进行性的组织纤维化。肾间质纤维化和肾性贫血是慢性肾脏病的常见并发症。介导肾间质纤维化的关键细胞是激活的肌成纤维细胞,而介导肾性贫血的重要因素则为肾促红细胞生成素产生细胞的减少,导致促红细胞生成素分泌下降。肾促红细胞生成素产生细胞向肌成纤维细胞的转化是慢性肾脏病贫血与纤维化之间联系的基础,且其转化具有可逆性。近年来研究人员试图为治疗慢性肾脏病贫血与纤维化寻找替代疗法,中药因其独特的优势已越来越多地用于治疗慢性肾脏病。该文主要探讨促红细胞生成素产生细胞与慢性肾脏病贫血和肾纤维化的关系,并对其相关中药研究现状进行阐述。The basic features of chronic kidney disease are persistent decline in renal function,accumulation of extracellular matrix,and progressive tissue fibrosis.Renal interstitial fibrosis and renal anemia are common complications of chronic kidney disease.Renal interstitial fibrosis is a chronic and progressive process.Its severity is closely related to renal dysfunction.Renal anemia may increase the incidence of cardiovascular complications and mortality in patients with chronic kidney disease.Therefore,it will be important to note the diagnosis and treatment of these two complications in the early stage of chronic kidney disease.The key cells mediating renal interstitial fibrosis are activated myofibroblasts,which are a major matrix-secreting cell type,and reactive cells mostly present under injury or pathological conditions;while the important factor mediating renal anemia is the reduction of erythropoietin-producing cells,which resulting in decreased secretion of erythropoietin(which is a glycoprotein hormone that promotes erythropoiesis).In addition,the transformation of erythropoietin-producing cells into myofibroblasts underlies the link between anemia and fibrosis in chronic kidney disease,and the transformation is reversible.Targeting this may open a new way for the treatment of renal anemia and renal interstitial fibrosis.In recent years,researchers have tried to find alternative therapies for the treatment of anemia and fibrosis in chronic kidney disease,and traditional Chinese medicine has been increasingly used to treat chronic kidney disease because of its unique advantages.The relationship has been mainly discussed in present paper between erythropoietin-producing cells and anemia and fibrosis in chronic kidney disease,and the current research status of traditional Chinese medicine is then analyzed and summarized.

关 键 词：促红细胞生成素产生细胞 肾性贫血 肾间质纤维化 慢性肾脏病 中药 

分 类 号：R692[医药卫生—泌尿科学]