苦参碱和氧化苦参碱抗大肠癌药理作用研究进展  

Research advances in pharmacologic effects of matrine and oxymatrine against large intestine carcinoma

作　　者：张明发[1] 沈雅琴[1] ZHANG Mingfa;SHEN Yaqin(Shanghai Meiyou Pharmaceutical Co.Ltd,Shanghai 201204,China)

机构地区：[1]上海美优制药有限公司,上海201204

出　　处：《药物评价研究》2020年第6期1189-1196,共8页Drug Evaluation Research

摘　　要：苦参碱和氧化苦参碱能防治氧化偶氮甲烷/葡聚糖硫酸钠诱发小鼠原发性结直肠癌和CT26细胞或SW480-EGFP细胞移植瘤在大鼠或小鼠体内生长。体外实验发现苦参碱和氧化苦参碱能浓度相关地抑制大肠癌SW480细胞、SW480-EGFP细胞、SW480/M5细胞、SW620细胞、SW1116细胞、LoVo细胞、HT-29细胞、Colon26细胞、HCT116细胞、HCT-8细胞、HCL细胞和LS174t细胞增殖,并诱导凋亡。苦参碱能增强奥沙利铂抗SW480细胞、SW620细胞和SW1116细胞的作用。氧化苦参碱能增强5-氟尿嘧啶抗LoVo细胞的作用。Matrine and oxymatrine have the effects in the prophylaxis and treatment of mice primary colorectal carcinoma induced by azoxymethane/dextran sulfate sodium and growth of transplantation tumor of large intestine carcinoma CT26 cells or SW480-EGFP cells in rats or mice.Matrine and oxymatrine inhibit proliferation and induce apoptosis in association with dosage on large intestine carcinoma SW480 cells,SW480-EGFP cells,SW480/M5 cells,SW620 cells,SW1116 cells,LoVo cells,HT-29 cells,Colon26 cells,HCT116 cells,HCT-8 cells,HCL cells,LS174t cells in vitro.Matrine can promote the effects of oxaliplatin against SW480 cells,SW620 cells,and SW1116 cells.Oxymatrine can promote the effect of fluorouracil against LoVo cells.

关 键 词：苦参碱 氧化苦参碱 抗肿瘤 大肠癌 

分 类 号：R285.6[医药卫生—中药学] R286.5[医药卫生—中医学]