混悬型滴眼剂的研究进展  

Research Progress of Ophthalmic Suspension

作　　者：易婷 赵雁[1] 陶涛[1] YI Ting;ZHAO Yan;TAO Tao(National Pharmaceutical Engineering and Research Center,China State Institute of Pharmaceutical Industry,Shanghai 201203)

机构地区：[1]中国医药工业研究总院药物制剂国家工程研究中心,上海201203

出　　处：《中国医药工业杂志》2020年第6期679-686,共8页Chinese Journal of Pharmaceuticals

摘　　要：混悬型滴眼剂系指难溶性固体药物以微粒状态分散于分散介质中形成的无菌眼用液体制剂。相较于溶液型滴眼剂,该剂型具有药物颗粒可在角膜前囊滞留、增加与角膜的接触时间从而提高药效的优势。目前国产混悬型滴眼剂品种较少,其开发存在较大挑战。本文从混悬型滴眼剂的国外品种概况、处方和工艺特点及其制剂学评价方法等方面介绍其研究进展。Ophthalmic suspension is a sterile liquid preparation formed by dispersing insoluble solid drugs in a dispersion medium.Compared with the ophthalmic solution,the ophthalmic suspension can improve the efficacy by prolonging the retention time of the active ingredient in the anterior corneal sacs.There are a few domestic products,because the development of ophthalmic suspension has great challenges.This paper focuses on the research progress of ophthalmic suspension,and provides an overview of its formulation,production progress and evaluation methods.

关 键 词：混悬型滴眼剂 处方 工艺 制剂学评价 

分 类 号：R944.9[医药卫生—药剂学]