三味龙胆花片联合盐酸头孢他美酯片治疗急性咽喉炎的疗效及对血清炎症因子水平的影响  

Efficacy of Sanwei Longdanhua Tablets Combined with Cefetamet Pivoxil Hydrochloride Tablets in the Treatment of Acute Laryngitis and its Effect on Serum Inflammatory Factor Levels

作　　者：张静 李鹏 李辉 黄静 ZHANG Jing;LI Peng;LI Hui;HUANG Jing(Dept. of Otolaryngology, Head and Neck Surgery, Wuhan Puren Hospital, Hubei Wuhan 430081, China;Dept. of General Surgery, Wuhan Yaxin General Hospital, Hubei Wuhan 430056, China;Dept. of TCM Acupuncture, Wuhan Puren Hospital, Hubei Wuhan 430081, China;Dept. of Nursing, Wuhan Puren Hospital, Hubei Wuhan 430081, China)

机构地区：[1]武汉市普仁医院耳鼻咽喉头颈外科,湖北武汉430081 [2]武汉亚心总医院普外科,湖北武汉430056 [3]武汉市普仁医院中医针灸科,湖北武汉430081 [4]武汉市普仁医院护理部,湖北武汉430081

出　　处：《中国医院用药评价与分析》2020年第5期551-553,共3页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：湖北省卫生健康委员会联合基金项目(No.WJ2019H153)。

摘　　要：目的:探讨三味龙胆花片联合盐酸头孢他美酯片治疗急性咽喉炎的疗效及对血清炎症因子水平的影响。方法:选取2016年10月至2019年10月武汉市普仁医院收治的急性咽喉炎患者120例,采用随机数字表法将患者分为观察组及对照组,每组60例。对照组患者口服盐酸头孢他美酯片治疗,观察组患者在对照组的基础上口服三味龙胆花片。观察两组患者的临床疗效、症状减退或消失时间、血清炎症因子[超敏C反应蛋白(hs-CRP)、白细胞介素1β(IL-1β)、白细胞介素6(IL-6)及肿瘤坏死因子α(TNF-α)]水平及不良反应发生情况。结果:观察组患者的总有效率为96.7%(58/60),明显高于对照组的88.3%(53/60),差异有统计学意义(χ^2=10.421,P<0.05)。观察组患者咽喉痛消失时间、发热减退时间、咽喉异物感消失时间及咽喉黏膜充血消失时间明显短于对照组,差异均有统计学意义(t分别为8.544、9.542、7.254及8.545,P均<0.05)。与治疗前相比,两组患者治疗后hs-CRP、IL-1β、IL-6及TNF-α表达水平明显降低,差异均有统计学意义(P<0.05);与对照组相比,观察组患者治疗后hs-CRP、IL-1β、IL-6及TNF-α表达水平明显降低,差异均有统计学意义(P<0.05)。观察组、对照组患者的不良反应发生率分别为1.7%(1/60)、3.3%(2/60),差异无统计学意义(χ^2=1.494,P>0.05)。结论:三味龙胆花片联合盐酸头孢他美酯片治疗,可以明显提高急性咽喉炎患者的疗效,并降低患者血清炎症因子表达水平。OBJECTIVE:To probe into the efficacy of Sanwei Longdanhua tablets combined with Cefetamet pivoxil hydrochloride tablets in the treatment of acute laryngitis and its effect on serum inflammatory factor levels.METHODS:Totally 120 patients with acute laryngitis admitted into Wuhan Puren Hospital from Oct.2016 to Oct.2019 were selected and divided into observation group and control group via random number table,with 60 cases in each group.The control group were treated with Cefetamet pivoxil hydrochloride tablets,while the observation group was given Sanwei Longdanhua tablets based on the control group.The clinical efficacy,remission or disappearance times of symptoms,serum inflammatory factor levels[hypersensitive C-reactive protein(hs-CRP),interleukin-1β(IL-1β),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)]and incidences of adverse drug reactions of both groups were observed.RESULTS:The total effective rate of observation group was 96.7%(58/60),which was significantly higher than that of the control group(88.3%,53/60),with statistically significant difference(χ^2=10.421,P<0.05).The disappearance time of sore throat,remission time of fever,disappearance times of foreign body sensation and mucosal congestion in throat of observation group were significantly shorter than those of the control group,with statistically significant differences(t=8.544/9.542/7.254/8.545,P<0.05).Compared with before treatment,the expression levels of hs-CRP,IL-1β,IL-6 and TNF-αof both groups were significantly lower than those of after treatment,with statistically significant differences(P<0.05);compared with the control group,the expression levels of hs-CRP,IL-1β,IL-6 and TNF-αof observation group were significantly lower after treatment,with statistically significant differences(P<0.05).The incidences of adverse drug reactions of observation group and control group were respectively 1.7%(1/60)and 3.3%(2/60),the difference had no statistical significance(χ^2=1.494,P>0.05).CONCLUSIONS:The combination of Sanwei Longdanhua t

关 键 词：三味龙胆花片 盐酸头孢他美酯 急性咽喉炎 血清炎症因子 

分 类 号：R932[医药卫生—生药学]