山东地区成人先天性心脏病流行病学特征调查及相关影响因素分析  

Investigation on epidemiological characteristics and analysis on related factors of adult congenital heart disease in Shandong area

作　　者：梁晨[1] 葛维媛[1] 刘宁[1] Liang Chen;Ge Weiyuan;Liu Ning(Department of Cardiology,Qingdao Municipal Hospital,Shandong Province,Qingdao 266000,China.)

机构地区：[1]青岛市市立医院心内科,青岛266000

出　　处：《中国循证心血管医学杂志》2020年第6期736-738,741,共4页Chinese Journal of Evidence-Based Cardiovascular Medicine

摘　　要：目的 分析山东地区成人先天性心脏病(ACHD)流行病学特征及相关影响因素.方法 抽取本研究协作单位18岁以上的健康体检人员、门诊和住院患者共83767例,调查ACHD患病情况并分析相关影响因素.结果 83767例调查对象中共发现ACHD患者296例,总患病率3.53‰;不同性别和民族间患病率无明显差异,而不同年龄段患病率差异有统计学意义(P<0.05);在296例ACHD患者中房间隔缺损占比例最高(33.45%),其次为法洛四联症(14.19%)、室间隔缺损(9.80%);296例ACHD患者中轻微型136例(轻微组),中、重度160例(中重组),两组患者的年龄、性别、NYHA心功能分级、手术次数和心脏药物使用比例等方面均有统计学差异(P<0.05);多因素Logistic回归分析显示孕早期病毒感染史和用药史为ACHD的危险因素(P<0.05).结论 孕早期病毒感染史和用药史为诱发ACHD的危险因素,应提高人群孕期保健意识和加强对ACHD患者的健康管理.Objective To analyze the epidemiological characteristics and related factors of adult congenital heart disease(ACHD)in Shandong area.Methods A total of 83767 health physical examination personnel,outpatients and inpatients aged over 18 years old were chosen,and ACHD prevalence was investigated and related influence factors were analyzed.Results There were totally 296 patients with ACHD in 83767 subjects,and the total prevalence rate was 3.53‰.There was no significant difference in prevalence rate among different genders and nationalities,but the difference in prevalence rate had statistical significance among different age groups(P<0.05).Among 296 patients with ACHD,the proportion of patients with atrial septal defect(ASD)was the highest(33.45%),followed by tetralogy of Fallot(TOF,14.19%)and ventricular septal defect(VSD,9.80%).Among 296 patients with ACHD,there were 136 patients with mild ACHD(mild group)and 160 with moderate-severe ACHD(moderate-severe group).There was statistical difference in age,sex,NYHA heart function classification,number of operations proportion of cardiac drug administration between 2 groups(P<0.05).The results of multi-factor regression analysis showed that history of virus infection in early pregnancy and history of medication were risk factors for ACHD(P<0.05).Conclusion Early pregnancy and history of medication are risk factors inducing ACHD.The consciousness of pregnancy care should be improved and health management of ACHD patients should be strengthened.

关 键 词：山东地区 成人先天性心脏病 流行病学特征 影响因素 

分 类 号：R541.1[医药卫生—心血管疾病]