血清脑啡肽酶与慢性心力衰竭的相关性研究  

Study on the correlation between serum enkephalinase and chronic heart failure

作　　者：刘赛磊 张雪娥[1] 靳妮 赵朵 Liu Sailei;Zhang Xue'e;Jin Ni;Zhao Duo(Department of Cardiovascular Medicine,Second Hospital of Shanxi Medical University,Taiyuan 030000,China.;不详)

机构地区：[1]山西医科大学第二医院心血管内科,太原030000 [2]山西医科大学第二医院肾内科,太原030000

出　　处：《中国循证心血管医学杂志》2020年第6期748-751,共4页Chinese Journal of Evidence-Based Cardiovascular Medicine

摘　　要：目的 研究血清脑啡肽酶(NEP)在不同级别心功能患者中的变化,并评估与其相关性.方法 选取2018年9月至2019年4月于山西医科大学第二医院心内科住院治疗并行心脏彩超及脑钠肽(BNP)的患者58例为心力衰竭(心衰)组,并选取同一时段于我院行健康体检者26例为对照组.结果 ①心衰组患者血清NEP水平(435.91±86.12)pg/ml,较对照组(555.99±116.75)pg/ml降低,差异有统计学意义(P=0.001);②心衰组的不同心功能级别NEP水平分别为:心功能Ⅱ级组:(475.38±92.97)pg/ml;心功能Ⅲ级组:(418.45±67.32)pg/ml;心功能Ⅳ级组:(409.39±72.93)pg/ml,Ⅲ级、Ⅳ级组NEP水平较Ⅱ级组显著降低,差异有统计学意义(P=0.037;P=0.036);③心衰组患者的左房内径(LA)、左室舒张末期内径(LVEDD)较正常组增大,差异有统计学意义(P=0.001;P=0.026);④心衰组中不同射血分数级别的NEP水平,各组之间无统计学意义(P>0.05);⑤心衰组各组间患者的BNP、射血分数水平(EF值)、LA及LVEDD与血清NEP水平之间无明显相关性(P>0.05).结论 NEP水平可以为慢性心力衰竭的诊断提供新的实验室检查证据.Objective To study the changes of serum enkephalinase(NEP)in patients with different levels of cardiac function and to evaluate their correlation.Methods From September 2018 to April 2019,58 patients who were admitted to the Department of Cardiology of the Second Hospital of Shanxi Medical University and treated with cardiac color Doppler ultrasound and B-type natriuretic peptide(BNP)were selected as the heart failure group.Twenty-six healthy persons undergoing health check-up in our hospital were the control group.Results The serum NEP level in the heart failure group(435.91±86.12)pg/ml was lower than that in the control group(555.99±116.75)pg/ml,and the difference was statistically significant(P=0.001).The NEP levels of different cardiac function levels in the heart failure group are:cardiac function classⅡgroup(475.38±92.97)pg/ml,cardiac function classⅢgroup(418.45±67.32)pg/ml,cardiac function classⅣgroup(409.39±72.93)pg/ml.The levels of NEP in groupⅢandⅣwere significantly lower than those in groupⅡ,and the difference was statistically significant(P=0.037;P=0.036).The LA and LVEDD in the heart failure group increased compared with the normal group,and the difference was statistically significant(P=0.001;P=0.026).The NEP levels of different ejection fraction levels in the heart failure group were not statistically significant among the groups(P>0.05).There was no significant correlation between BNP,ejection fraction level(EF value),LA,LVEDD and serum NEP level among the heart failure groups(P>0.05).Conclusion NEP levels can provide new laboratory evidence for the diagnosis of chronic heart failure.

关 键 词：心力衰竭 脑啡肽酶 左心功能 心功能分级(NYHA分级) 射血分数 

分 类 号：R541.61[医药卫生—心血管疾病]