空腹血糖受损患者血尿酸与肾小球滤过率的相关性分析  

Relationship between serum uric acid and glomerular filtration rate in patients with impaired fasting glucose

作　　者：拾莉 刘学奎[2,3] 龚莹[2] 桑谊荃 梁军[2,3] SHI Li;LIU Xue-kui;GONG Ying;SANG Yi-quan;LIANG Jun(Xuzhou Institute of Medical Sciences, Xuzhou Jiangsu 221006;Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Jiangsu 221009;Xuzhou Institute of Diabetes Mellitus, Xuzhou Jiangsu 221006, China)

机构地区：[1]徐州市医学科学研究所,江苏徐州221006 [2]徐州市中心医院内分泌科,江苏徐州221009 [3]徐州市糖尿病研究所,江苏徐州221006

出　　处：《江苏大学学报（医学版）》2020年第4期347-350,共4页Journal of Jiangsu University：Medicine Edition

基　　金：江苏省卫生厅资助项目(H201356);徐州市科技局社会发展项目(KC18195)。

摘　　要：目的:探讨社区人群中空腹血糖受损(impaired fasting glucose,IFG)患者血尿酸与肾小球滤过率(GFR)的相关性,评估空腹血糖水平与血尿酸的交互作用对GFR的影响。方法:选择徐州地区2016年在徐州市中心医院体检者11078例为研究对象,根据空腹血糖水平分为正常血糖组(空腹血糖3.8~6.0 mmol/L)和空腹血糖受损组(空腹血糖6.1~7.0 mmol/L)。比较两组血压、BMI、血脂、γ-谷氨酰转肽酶(GGT)等相关生化指标。估算肾小球滤过率(eGFR)采用中国慢性肾脏疾病患者资料校正的MDRD公式。空腹血糖受损组血尿酸与eGFR的关系采用一般线性回归方程。结果:随着血尿酸的增高,空腹血糖受损患者的eGFR呈降低趋势,趋势P值<0.001;校正性别、年龄、BMI、血压、血脂等指标后,eGFR仍随血尿酸的升高而降低,其趋势有统计学意义(P<0.001)。空腹血糖水平与血尿酸对eGFR的变化存在交互作用(P=0.035)。结论:血清尿酸水平是空腹血糖受损患者eGFR的独立危险因素,且空腹血糖受损合并高血清尿酸水平会使eGFR进一步下降。Objective:To investigate the correlation between serum uric acid and glomerular filtration rate(GFR)in patients with impaired fasting glucose(IFG)in community population,and to evaluate the effect of interaction between fasting blood glucose and serum uric acid on GFR.Methods:The subjects were 11078 people who had physical examination in Xuzhou Central Hospital in 2016.They were divided into normal blood glucose group(3.8-6.0 mmol/L)and IFG group(6.1-7.0 mmol/L).The blood pressure,BMI,blood lipid and GGT were compared between the two groups.The estimated glomerular filtration rate(eGFR)was estimated using the MDRD formula corrected by the data of Chinese patients with chronic kidney disease.The correlation between serum uric acid and eGFR in patients with IFG was analyzed by univariate linear regression.Results:With the increase of serum uric acid,the eGFR of IFG patients showed a decreasing trend with the trend P value<0.001.After adjusting for sex,age,BMI,blood pressure,blood lipid and other indicators,the eGFR still decreased with the increase of serum uric acid,and the trend was statistically significant(P<0.001).There was an interaction between fasting blood glucose level and serum uric acid on the changes of eGFR(P=0.035).Conclusion:Serum uric acid level is an independent risk factor of eGFR in IFG patients,and can interact with fasting blood glucose level to further reduce eGFR.

关 键 词：空腹血糖受损 血尿酸 肾小球滤过率 糖尿病肾病 

分 类 号：R587.2[医药卫生—内分泌]