白介素-17在原发性膜性肾病患者血清和尿液中的表达  

Expression of interleukin-17 in serum and urine of patients with primary membranous nephropathy

作　　者：王群文 刘晓刚[2] 解汝娟[2] 高芃 刘亚楠[2] 刘先双 WANG Qunwen;LIU Xiaogang;XIE Rujuan;GAO Peng;LIU Yanan;LIU Xianshuang(Department of Emergency Medicine, Wuxi People's Hospital Affiliated To Nanjing Medical University,Wuxi 214000, Jiangsu, China;Department of Nephrology, The First Affiliated Hospital, Harbin Medical University, Harbin 150000, China)

机构地区：[1]南京医科大学附属无锡人民医院急诊内科,江苏无锡214000 [2]哈尔滨医科大学附属第一医院肾内科,黑龙江哈尔滨150000

出　　处：《西部医学》2020年第7期1045-1048,共4页Medical Journal of West China

摘　　要：目的探讨IL-17在原发性膜性肾病中的作用。方法选取2016年6月~2018年2月哈尔滨医科大学附属第一医院43例原发性膜性肾病的患者,按照病理分期分为Ⅰ、Ⅱ、Ⅲ期3组,对所有患者的一般情况、实验室检查以及肾活检病理结果进行统计分析;另将43例患者按照有无肾小管及间质损伤分组,分析IL-17与原发性膜性肾病患者肾小管及间质损伤的关系。结果Ⅱ期和Ⅲ期血清IL-17水平高于Ⅰ期(P<0.05),Ⅲ期尿液IL-17水平高于Ⅱ期(P<0.05),Ⅲ期高于Ⅰ期和Ⅱ期(P<0.05);不同肾小管间质损伤程度的患者血清和尿液IL-17表达水平比较差异均有统计学意义(P<0.05)。结论IL-17与原发性膜性肾病患者肾小管及间质损伤有关。Objective The purpose of our study was to observe the expression of IL-17 in serum and urine of patients with PMN and to explore the possible role of IL-17 in PMN.Methods From June 2016 to February 2018,43 patients with primary membranous nephropathy were selected from the First Affiliated Hospital of Harbin Medical University.According to the pathological stages,the patients were divided into three groups:stageⅠ,stageⅡand stageⅢ.The general situation,laboratory examination and pathological results of renal biopsy were statistically analyzed.In addition,43 patients were divided into groups according to whether there was renal tubule and interstitial damage,and the relationship between IL-17 and renal tubule and interstitial damage in patients with primary membranous nephropathy was analyzed.Results The level of serum IL-17 in stageⅡand stageⅢwas higher than that in stageⅠ,with statistical difference(P<0.05).The level of urine IL-17 in stageⅢwas higher than that in stageⅡ,with statistical difference(P<0.05).The level of serum and urine IL-17 in stageⅢwas higher than that in stageⅠand stageⅡ(P<0.05).The level of serum and urine IL 17 in patients with different degrees of tubulointerstitial injury was statistically different(P<0.05).Conclusion IL-17 is associated with renal tubular and interstitial injury in patients with primary membranous nephropathy.

关 键 词：白介素-17 原发性膜性肾病 肾病综合征 肾小管间质损伤 

分 类 号：R692.31[医药卫生—泌尿科学]