热休克蛋白在风湿性疾病中的研究进展  

Research progress of heat shock protein in rheumatic diseases

作　　者：周菊(综述) 李梦兰 何馨怡 帅世全(审校) ZHOU Ju reviewing;LI Menglan;HE Xinyi;SHUAI Shiquan checking(Department of Rheumatology,Nanchong Central Hospital,The Second Clinical Medical College of North Sichuan Medical College,Nanchong 637000,Sichuan,China)

机构地区：[1]南充市中心医院·川北医学院第二临床医学院风湿免疫科,四川南充637000

出　　处：《西部医学》2020年第7期1090-F0003,共4页Medical Journal of West China

基　　金：国家自然科学基金资助项目(81272047);南充市市校科技战略合作项目(18SXHZ0077)。

摘　　要：风湿性疾病泛指影响骨、关节及其周围软组织的一组疾病,其病因包括感染性、免疫性、代谢性、内分泌性、退行性、遗传性、肿瘤性等等。热休克蛋白(HSPs)是一类高度保守的应激蛋白家族,在炎症、免疫、代谢反应中起重要作用。研究发现热休克蛋白可能与风湿性疾病的发生、发展有关,但具体作用及机制尚不清楚。本文就近年来热休克蛋白在风湿性疾病中的研究进展做一综述。Rheumatic disease refers to a group of diseases affecting bone,joints and surrounding soft tissues.Its etiology includes infectivity,immunity,metabolic,endocrine,degenerative,hereditary,tumorigenic and so on.Heat shock proteins(HSPs)are a highly conserved family of stress proteins,which play an important role in inflammatory,immune and metabolic reactions.It was found that the level of HSP70 in serum of patients with rheumatoid arthritis was increased,HSP90 inhibitors could alleviate the inflammatory reaction of lupus mice,and the expression of HSP70 in synovium of patients with osteoarthritis was up-regulated.All these indicate that Heat shock proteins may be related to the occurrence and development of rheumatic diseases,but the specific role and mechanism are still unclear.This article reviews the research progress of Heat shock proteins in rheumatic diseases in recent years.

关 键 词：热休克蛋白 关节炎 风湿性疾病 类风湿关节炎 系统性红斑狼疮 骨关节炎 

分 类 号：R593.2[医药卫生—内科学]