分析高脂血症患者长期口服二甲双胍联合瑞舒伐他汀治疗的临床疗效及安全性  

To analyze the clinical efficacy and safety of long-term oral metformin combined with rosuvastatin in patients with hyperlipidemia

作　　者：刘现翠[1] 单鹏[2] Liu Xiancui;Shan Peng(Ji'nan Third People's Hospital,Ji'nan 250132,Shandong,China;Tengzhou Central People's Hospital,Tengzhou 277599,Shandong,China)

机构地区：[1]济南市第三人民医院,山东济南250132 [2]滕州市中心人民医院,山东滕州277599

出　　处：《医院与医学》2020年第2期39-43,共5页Hospital and Medicine

摘　　要：目的分析二甲双胍联合瑞舒伐他汀长期口服治疗高脂血症的临床疗效及安全性。方法将2016年5月-12月某院收治的73例高脂血症患者作为实验组,予以二甲双胍联合瑞舒伐他汀治疗,同期遵循1∶1配对原则将另73例高脂血症患者作为对照组,予以二甲双胍治疗,两组均在用药第3、6、12个月时观察疗效,并对药物长期口服的安全性进行对比分析。结果两组患者治疗第3、6、12个月后的血脂指标较治疗前明显改善(P<0.05);实验组治疗后各时间段的治疗总有效率明显高于对照组(P<0.05)。两组患者各时间段复查尿常规、肝肾功能等各项指标,未见严重的不良反应事件(P>0.05);治疗期间有个别患者出现胃肠副反应、乏力、瘙痒等,但均为短暂性或轻度,两组间无统计学差异(P>0.05)。结论长期口服二甲双胍与瑞舒伐他汀治疗高脂血症,临床疗效显著,安全性高,属于比较合理的用药方案。Objective To analyze the clinical efficacy and safety of metformin combined with rosuvastatin for long-term oral treat⁃ment of hyperlipidemia.Methods Seventy-three patients with hyperlipidemia treated in a hospital from May 2016 to December 2016 were treated with metformin combined with rosuvastatin as the experimental group,and another 73 patients with hyperlipidemia were treated with metformin as the control group according to the 1:1 matching principle.The efficacy of the two groups was observed at 3,6 and 12 months of drug administration,and the safety of long-term oral administration of the drug was compared and analyzed.Results The blood lipid index of the two groups after 3,6 and 12 months of treatment was significantly improved compared with that before treatment(P<0.05);the total effective rate of the experimental group was significantly higher than that of the control group at each time period after treatment(P<0.05).There were no serious adverse reactions(P>0.05)in urine routine examination,liver and kidney function and other indicators in both groups during each time period.During the treatment period,there were some gastrointesti⁃nal side effects,fatigue,pruritus in individual patients,but they were transient or mild,and there was no statistical difference between the two groups(P>0.05).Conclusion Long-term oral metformin and rosuvastatin treatment of hyperlipidemia,clinical efficacy is sig⁃nificant,high safety,belongs to a more reasonable drug regimen.

关 键 词：高脂血症 二甲双胍 瑞舒伐他汀 安全性 

分 类 号：R58[医药卫生—内分泌]