足外洗一号方术前浴足抑菌效果临床研究  

Clinical Study on Bacteriostatic Effect of Zuwaixi Yihao Formula(足外洗一号方)Before Foot and Ankle Surgery

作　　者：韩旭[1] 孙卫东 HAN Xu;SUN Weidong(Beijing Fengsheng Special Hospital of Traditional Medical Traumatology and Orthopaedics,Beijing 100033,China;Wangjing Hospital of China Academy of Chinese Medical Science,Beijing 100102,China)

机构地区：[1]北京市丰盛中医骨伤专科医院,北京100033 [2]中国中医科学院望京医院,北京100102

出　　处：《山东中医药大学学报》2020年第4期400-404,共5页Journal of Shandong University of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(编号:81373802)。

摘　　要：目的:观察足外洗一号方术前浴足的抑菌效果,为增强足踝部手术术前皮肤清洁、降低术后感染率提供试验依据。方法:选取60例受试者,依照随机原则将其双足分别纳入观察组及对照组,组成配对样本对子。模拟术前皮肤清洁程序,肥皂清洗后第一次取样。观察组应用足外洗一号方、对照组应用五味消毒饮足部泡洗30 min后第二次取样,最后双足套无菌足套12 h后第三次取样。依据培养结果计算出即时抑菌率和12 h增菌率、用药12 h实际抑菌率并进行比较。对用药48 h内皮肤刺激反应进行观察,评价用药安全性。结果:即时抑菌率观察组84.8%,对照组59.5%,两组疗效比较差异有统计学意义(P<0.05);泡洗后12 h,观察组足部菌群增菌率98.3%,对照组227.2%,两组疗效比较差异有统计学意义(P<0.05)。应用泡洗药物12 h后,观察组实际抑菌率74.8%,对照组-8.2%,差异有统计学意义(P<0.05);受试者完成试验48 h内观察,两组药物致敏反应率均为0。结论:术前浴足能够有效降低足踝部皮肤菌群数量,足外洗一号方即时抑菌效果以及12 h实际抑菌效果明显高于五味消毒饮,两种药物均安全可靠。Objectives:To observe the bacteriostatic effect of Zuwaixi Yihao Formula(足外洗一号方)used before foot and ankle surgery,and to provide experimental basis for enhancing the preoperative skin cleaning and reducing the postoperative infection rate.Methods:According to the random principle,total 60 subjects were enrolled into the observation group and the control group.Simulating the procedure of preoperative skin cleansing,and the first sample was taken after washing with soap.The second sample was taken after foot soaking for 30 min with Zuwaixi Yihao Formula in the observation group and Wuwei Xiaodu Drink(五味消毒饮)in the control group.Finally,the third sample was taken after 12 h of sterile bipedal cover.According to the results of culture,the immediate bacteriostatic rate,the 12 h bacteria increasing rate and the 12 h actual bacteriostatic rate were calculated and compared.The skin irritation was observed within 48 hours to evaluate the medication safety.Results:The immediate bacteriostatic rate was 84.8%in the observation group and 59.5%in the control group,the difference between the two groups was statistically significant(P<0.05).At 12 h after soaking,the bacteria increasing rate of foot flora was 98.3%in the observation group and 227.2%in the control group.The difference between the two groups was statistically significant(P<0.05).After the application of the soaking medicine for 12 h,the actual bactericidal rate in the observation group was 74.8%on average,and that in the control group was-8.2%on average.The difference was statistically significant(P<0.05).After 48 h observation,the drug allergy rate of both groups was 0.Conclusions:Foot soaking before surgery can effectively reduce the number of bacteria in the skin of the foot and ankle.Among them,the instant bacteriostatic effect and the 12 h actual bacteriostatic effect of Zuwaixi Yihao Formula are significantly higher than those of Wuwei Xiaodu Drink.Both are safe and reliable.

关 键 词：足踝部手术 足外洗一号方 五味消毒饮 足部泡洗 清热解毒燥湿 即时抑菌率 增菌率 实际抑菌率 

分 类 号：R275.910.5[医药卫生—中西医结合]