溃结方联合隔药灸治疗大肠湿热型溃疡性结肠炎疗效观察  

Observation on Curative Effect of Kuijie Formula(溃结方)Combined with Medicinal Moxibustion in Treating Ulcerative Colitis of Large Intestine Dampness-heat Type

作　　者：郑薇薇 潘林康 刘兴山[1] ZHENG Weiwei;PAN Linkang;LIU Xingshan(Weifang Hospital of Traditional Chinese Medicine,Weifang 261041,China)

机构地区：[1]潍坊市中医院,山东潍坊261041

出　　处：《山东中医药大学学报》2020年第4期410-413,共4页Journal of Shandong University of Traditional Chinese Medicine

基　　金：潍坊市中医药科研立项项目(编号:2015-3-010)。

摘　　要：目的:观察溃结方灌肠联合隔药灸对大肠湿热型溃疡性结肠炎(UC)的治疗作用。方法:纳入符合标准的80例轻中度大肠湿热型UC患者,按照随机数字表法分为治疗组与对照组各40例,对照组给予美沙拉嗪肠溶片,每次1 g,日4次;治疗组以溃结方灌肠联合隔参苓白术散艾灸神阙穴治疗,连续治疗4周。评价治疗后两组患者血清白细胞介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)及中医症状积分、中医证候疗效、Baron内镜积分。同时选择40例健康体检者为正常组,检测IL-10、TNF-α水平作为基线。结果:两组治疗后血清IL-10、TNF-α及中医症状积分、中医证候疗效、Baron内镜积分均较治疗前改善,两组治疗后血清IL-10、TNF-α水平比较差异无统计学意义(P>0.05),但与正常组比较差异均有统计学意义(P<0.05)。两组治疗后Baron内镜积分比较差异无统计学意义(P>0.05)。治疗组在改善患者腹痛、腹泻、里急后重方面优于对照组(P<0.05),在改善患者黏液脓血便方面与对照组比较差异无统计学意义(P>0.05)。结论:溃结方联合隔药灸治疗大肠湿热型溃疡性结肠炎在改善患者临床症状、减轻肠道炎症方面优于美沙拉嗪口服治疗。Objective:To observe the therapeutic effect of Kuijie Formula(溃结方)enema combined with medicinal moxibustion on ulcerative colitis(UC)of large intestine damp-heat type.Methods:A total of 80 patients with mild to moderate UC of large intestine damp-heat type who met the criteria were included.According to the random number table method,patients were divided into the treatment group and the control group,40 patients in each group.The control group was treated with mesalazine enteric-coated tablets 1 g,4 times a day,and the treatment group was treated with Kuijie Formula enema combined with medicinal moxibustion on Shenque(CV8)piont with Shenling Baizhu Powder(参苓白术散),continued for 4 weeks.After treatment,serum interleukin-10(IL-10),tumor necrosis factorα(TNF-α),traditional Chinese medicine(TCM)symptom score,TCM syndrome effect,Baron endoscopy score of the two groups were observed.At the same time,40 case healthy subjects were selected as normal group,serum IL-10 and TNF-αlevels were detected as the baseline.Results:IL-10,TNF-α,TCM syndrome score,TCM syndrome effect and Baron endoscopy score were all improved in the two groups after treatment.No statistical significance were found in IL-10,TNF-αbetween the two groups after treatment(P>0.05),but there were a statistical significance compared with the normal group(P<0.05).After treatment,there was no statistical significance in Baron endoscopic scores between the two groups(P>0.05).The treatment group was superior to the control group in improving patients’abdominal pain,diarrhea and tenesmus(P<0.05).There was no statistical significance between the two groups in improving patients’mucopurulent bloody stool.Conclusion:Kuijie Formula enema combined with medicinal moxibustion treating ulcerative colitis is superior to the oral treatment of mesalazine in improving the clinical symptoms and alleviating intestinal inflammation.

关 键 词：溃疡性结肠炎 大肠湿热型 溃结方 参苓白术散 隔药灸 中医症状积分 中医证候疗效 Baron内镜积分 炎症因子 

分 类 号：R259.746.2[医药卫生—中西医结合]