巨型先天性黑色素细胞痣恶变并多发转移一例报告并文献复习  

Giant congenital melanocytic nevus and malignant transforation:a case report and literature review

作　　者：唐京京[1] 赵晓明[1] 盛光耀[1] Tang Jingjing;Zhao Xiaoming;Sheng Guangyao(Department of Pediatric Hematology and Oncology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学第一附属医院儿童血液肿瘤科,450000

出　　处：《中国实用医刊》2020年第4期122-122,F0003,F0004,共3页Chinese Journal of Practical Medicine

摘　　要：目的探讨巨型先天性黑色素细胞痣(GCMN)恶变多发转移的诊断及鉴别诊断方法。方法回顾性分析2017年7月郑州大学第一附属医院收治的1例GCMN患儿的临床特征及各项辅助检查(包括影像学及实验室)结果,并复习相关文献。结果综合影像学、病理学、骨髓细胞学、免疫组织化学、流式细胞学等多项检查及临床症状,该例患者诊断为GCMN恶变并肝脏、骨髓转移。结论恶性黑色素瘤恶变骨髓转移的诊断主要依靠骨髓穿刺涂片形态学检查。从临床症状、病理诊断、细胞形态学及细胞化学染色综合分析考虑为恶性黑色素瘤骨髓转移。Objective To investigate the diagnosis and differential diagnosis of malignant transformation in children with giant congenital melanocyte nevus (GCMN).Methods The clinical features and results of various auxiliary examinations (including imaging and laboratory) from one GCMN child treated in the First Affiliated Hospital of Zhengzhou University in July 2017 were retrospectively analyzed. And related literature was reviewed.Results Results of imaging, pathology, bone marrow cytology, immunohistochemistry, flow cytology and other examinations and clinical symptoms were synthetically considered. As a result, this case was diagnosed with malignant GCMN with hepatic and bone-marrow metastases.Conclusions The diagnosis of bone marrow metastasis of malignant melanoma mainly depends on the morphological examination of bone marrow biopsy smear. The definite diagnosis of bone marrow metastasis of malignant melanoma depends on the comprehensive analysis of clinical symptoms, pathological diagnosis, cell morphology and cytochemical staining.

关 键 词：巨型先天性黑色素细胞痣 骨髓细胞学 病理学 

分 类 号：R758[医药卫生—皮肤病学与性病学]