198例围产期妇女不规则抗体特异性分布的研究  

Study on specificity distribution of irregular antibody in 198 cases of perinatal women

作　　者：周娜 李柯成 吕红娟[1] 李京[1] 潘英芳 宋永红[1] 徐群[1] ZHOU Na;LI Kecheng;LV Hongjuan;LI Jing;PAN Yingfang;SONG Yonghong;XU Qun(Blood Group Reference Laboratory,Shandong Blood Center,Jinan 250014,China;Jinan Central Hospital Affiliated to Shandong University,Medical Research&Laboratory Diagnostic Center Corresp)

机构地区：[1]山东省血液中心血型参比研究室,山东济南250014 [2]山东大学附属济南市中心医院医学实验诊断中心

出　　处：《中国输血杂志》2020年第4期370-373,共4页Chinese Journal of Blood Transfusion

摘　　要：目的分析山东地区围产期女性血型不规则抗体特异性分布。方法收集2015年1月—2018年12月,山东驻济省级医院送检的围产期女性不规则抗体筛查阳性血液标本198例,采用试管盐水法、经典抗球蛋白方法及微柱凝胶法进行抗体筛查和抗体特异性鉴定。结果198例抗体初筛阳性标本中,特异性同种抗体主要分布于Rh、MNSs、Lewis、Diego、Duffy等血型系统,其中最常见的特异性抗体是Rh系统的抗-E(53例,26.8%),其次是抗-D(39例,19.7%);除Rh系统之外,最常见的是MNSs系统的抗-M(36例,18.2%)。结论围产期女性进行不规则抗体筛查对保障母婴安全至关重要。Objective To analyze the specificity distribution of irregular antibodies in perinatal women in Shandong province.Methods From January 2015 to December 2018,blood samples from 198 perinatal women,who came from local provincial hospitals in Jinan,were collected due to the positive irregular antibody screening results.The saline method,antiglobulin test and microcolumn gel test were used for the screening and specificity confirmation of antibody.Results Among the above 198 cases,the irregular antibodies detected were mainly distributed in Rh,MNSs,Lewis,Diego,Duffy and other blood group systems.The most frequent antibody was anti-E antibody of Rh blood group system(53 cases,26.8%),followed by anti-D antibody(39 cases,19.7%).In addition to the Rh system,anti-M antibody(36 cases,18.2%)of MNSs blood group system was found to be the most common one.Conclusion It is very important to do prenatal screening of irregular antibody,which can ensure the safety of lying-in women and infants.

关 键 词：不规则抗体 围产期 抗体特异性 抗体鉴定 

分 类 号：R457.11[医药卫生—治疗学]