脑外伤所致精神障碍者冲动控制能力及ERP特征  

Impulse Control and ERP Characteristics of Patients with Mental Disorder Caused by Traumatic Brain Injury

作　　者：宋宏飞 邓茜[1] 杨宁 郝博[1] 胡喻博 时燕薇[1,2] 薛丽 赵虎[1,2] SONG Hong-fei;DENG Xi;YANG Ning;HAO Bo;HU Yu-bo;SHI Yan-wei;XUE Li;ZHAO Hu(Department of Forensic Medicine,Zhongshan School of Medicine,Sun Yat-sen University,Guangzhou 510080,China;Guangdong Province Translational Forensic Medicine Engineering Technology Research Center,Guangzhou 510080,China)

机构地区：[1]中山大学中山医学院法医学系,广东广州510080 [2]广东省法医学转化医学工程技术研究中心,广东广州510080

出　　处：《法医学杂志》2020年第3期326-332,共7页Journal of Forensic Medicine

基　　金：国家自然科学基金面上资助项目(81871535)。

摘　　要：目的探索司法精神病鉴定中脑外伤所致精神障碍者的冲动控制能力及其事件相关电位(eventrelated potential,ERP)特点,以期为司法精神病鉴定提供客观辅助指标。方法收集脑外伤所致精神障碍、经司法精神病鉴定为轻度精神障碍的患者(脑外伤组)30例,其中男性24例、女性6例,以及对照组30例。两组被试均需完成自评量表Barratt冲动性量表-11(Barratt Impulsiveness Scale-11,BIS-11)和Go/NoGo任务诱导的事件相关电位,收集并分析BIS-11及ERP数据。结果 BIS-11量表结果表明,脑外伤组的量表总得分及各维度得分高于对照组(P<0.05)。与对照组相比,脑外伤组的NoGo-N2波幅、NoGo-P3波幅低于对照组,两组中NoGo-N2波幅均大于Go-N2波幅,NoGo-P3波幅均大于Go-P3波幅(P<0.05)。结论脑外伤可致轻度精神障碍者冲动控制能力受损,NoGo-N2、NoGo-P3波幅可作为脑外伤所致精神障碍者冲动控制能力评定的重要参考指标。Objective To explore the impulse control and event-related potential(ERP)characteristics of patients with mental disorders caused by traumatic brain injury(TBI)in forensic psychiatry identification and to provide objective auxiliary indicators for forensic psychiatry identification.Methods Thirty patients(TBI group)with mental disorders caused by traumatic brain injury,who were identified as mild psychiatric impairment by judicial psychiatry,including 24 males and 6 females,as well as the thirty people in the control group participated in the study.All the participants completed Barratt Impulsiveness Scale-11(BIS-11)and ERP induced by Go/NoGo tasks.BIS-11 and ERP data were collected and analyzed.Results The results of the BIS-11 showed that the total score and subscale scores of the TBI group were higher compared to the control group(P<0.05).Moreover,the TBI group exhibited significantly lower NoGo-N2 amplitude and lower NoGo-P3 amplitude than the control group.The NoGo-N2 amplitude was larger than the Go-N2 amplitude,and the NoGo-P3 amplitude was larger than the Go-P3 amplitude in both groups(P<0.05).Conclusion Traumatic brain injury could impair impulse control of mild psychiatric impairment patients,and the amplitudes of NoGo-N2 and NoGo-P3 could be important parameters to evaluate the impulse control of patients with mental disorders caused by traumatic brain injury.

关 键 词：司法精神病学 精神障碍 脑损伤 冲动控制障碍 事件相关电位 Go/NoGo任务 Barratt冲动性量表-11 

分 类 号：D919.3[医药卫生—法医学]