足三里穴位注射银杏叶提取物对糖尿病周围血管病变患者下肢动脉血流、血液流变学及血管新生指标的影响  

Effects of Ginkgo Leaves Extract injection at Zúsanlǐ acupoint on arterial blood flow,hemorheology and angiogenesis index of lower extremity arteries in diabetic patients with peripheral vascular disease

作　　者：王景[1] 于洋[1] 张海丽[1] 回雪颖[1] 滕林[1] 郭伟光[1] 孙申田 WANG Jing;YU Yang;ZHANG Haili;HUI Xueying;TENG Lin;GUO Weiguang;SUN Shentian(Department of Peripheral Vascular Diseases,the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine,Heilongjiang Province,Harbin 150001,China)

机构地区：[1]黑龙江中医药大学附属第二医院周围血管病科,黑龙江哈尔滨150001

出　　处：《中国医药导报》2020年第18期81-86,共6页China Medical Herald

基　　金：第六批全国老中医药专家学术经验继承项目(国中医药办人教函[2017]125号);黑龙江省科学基金项目(H2017067);黑龙江省中医药管理局科研项目(ZHY12-Z050);黑龙江省中医药学会青年科技创新项目(ZHY19-052);黑龙江中医药大学科研基金项目(201812)。

摘　　要：目的研究足三里穴位注射银杏叶提取物对糖尿病周围血管病变(DPVD)患者血管新生指标的影响。方法选取2017年3月~2019年2月黑龙江中医药大学附属第二医院收治的94例DPVD患者,简单随机化分组,每组47例。对照组予以西医综合治疗,观察组加用足三里穴位注射银杏叶提取物,共治疗2周。比较两组治疗2周后的疗效,下肢动脉血流指标[波动指数(PI)、踝肱指数(ABI)、平均血流速度(Vmean)、阻力指数(RI)],血液流变学指标[血浆黏度(PV)、高切全血黏度(H-WBV)、中切全血黏度(M-WBV)、低全血切黏度(L-WBV)],血管新生指标[外周血内皮祖细胞(EPCs)数量、碱性成纤维细胞生长因子(bFGF)、血管内皮生长因子(VEGF)、血小板源性内皮细胞生长因子(PD-ECGF)]水平和不良反应。结果治疗2周后观察组总有效率高于对照组,差异有统计学意义(P <0.05);观察组治疗2周后,ABI、Vmean较治疗前升高,PI、RI较治疗前降低,差异均有统计学意义(均P <0.05);对照组治疗2周后,ABI较治疗前升高,RI较治疗前降低,差异均有统计学意义(均P <0.05),Vmean、PI与治疗前比较,差异无统计学意义(P> 0.05);观察组治疗2周后ABI、Vmean高于对照组,PI、RI低于对照组,差异均有统计学意义(均P <0.05);治疗2周后两组患者PV、H-WBV、M-WBV、L-WBV均低于治疗前,且观察组低于对照组,差异均有统计学意义(均P <0.05);治疗2周后两组患者EPCs、bFGF、VEGF、PD-ECGF均高于治疗前,且观察组高于对照组,差异均有统计学意义(均P <0.05);观察组不良反应发生率与对照组比较,差异无统计学意义(P> 0.05)。结论足三里穴位注射银杏叶提取物可改善DPVD患者下肢血流动力学,有效缓解患者症状体征,改善患者血液高凝状态,优化微循环,促进血管新生,安全可靠。Objective To study the effect of Ginkgo Leaves Extract injection at Zúsanlǐ acupoint on angiogenesis index in patients with diabetic peripheral vascular disease(DPVD).Methods A total of 94 DPVD patients who admitted to the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine from March 2017 to February 2019 were selected and simple randomization grouping was performed,with 47 patients in each group.The control group received integrated Western medicine treatment,and the observation group was added with Zúsanlǐ acupoint injection of Ginkgo Leaves Extract for a total of 2 weeks.The curative effect,arterial blood flow index of lower extremity(fluctuation index[PI],ankle brachial index[ABI],mean blood flow velocity[Vmean],resistance index[RI]),hemorheology index(plasma viscosity[PV],high cut in whole blood viscosity[H-WBV],mid cut whole blood viscosity[M-WBV],low cut whole blood viscosity[L-WBV]),angiogenesis indicators(number of peripheral blood endothelial progenitor cells[EPCs],basic fibroblast growth factor[bFGF],vascular endothelial growth factor[VEGF],platelet-derived endothelial cell growth factor[PD-ECGF])levels and adverse reactions of the two groups after 2 weeks of treatment were compared.Results After 2 weeks of treatment,the total effective rate of the observation group was higher than that of the control group,with statistically significant difference(P<0.05).After 2 weeks of treatment,ABI and Vmean in the observation group were increased compared with those before treatment,and PI and RI were decreased compared with those before treatment,with statistically significant differences(all P<0.05).ABI was increased and RI was decreased in the control group after 2 weeks of treatment compared with those before treatment,and the differences were statistically significant(all P<0.05).Vmean and PI were not statistically significant compared with those before treatment(P>0.05).After 2 weeks of treatment,ABI and Vmean of the observation group were higher than those of the control group,an

关 键 词：足三里 穴位注射 银杏叶提取物 糖尿病周围血管病变 血管新生指标 

分 类 号：R587[医药卫生—内分泌]