卡维地洛联合尼可地尔治疗老年冠心病心绞痛患者的效果及对sICAM-1和MPO水平的影响  

Effect of Carvedilol combined with Nicotil on elderly patients with coronary heart disease and angina pectoris and its effect on sICAM-1 and MPO levels

作　　者：吴威[1] 张婷 蒙奕兵 张雪 WU Wei;ZHANG Ting;MENG Yibing;ZHANG Xue(Department of Cardiovascular Medicine,Beijing Huimin Hospital,Beijing100054,China;Liver Disease Division,Beijing Ditan Hospital,Capital Medical University,Beijing100015,China;Department of Endocrinology,Fengtai Nanyuan Hospital,Beijing100076,China)

机构地区：[1]北京市回民医院心血管内科,北京100054 [2]首都医科大学附属北京地坛医院肝病科,北京100015 [3]北京市丰台区南苑医院内分泌科,北京100076

出　　处：《中国医药导报》2020年第18期139-142,共4页China Medical Herald

基　　金：北京市医院管理局消化内科学科协同发展中心消化专项特色项目(XXT27)。

摘　　要：目的探讨卡维地洛联合尼可地尔治疗老年冠心病心绞痛患者的效果及对可溶性细胞间黏附分子-1(sICAM-1)和髓过氧化物酶(MPO)水平的影响。方法选取2016年1月~2019年1月北京市回民医院收治的166例老年冠心病心绞痛患者作为研究对象。根据治疗方案分为对照组和研究组,每组各83例。对照组应用卡维地洛治疗,研究组在对照组基础上应用尼可地尔治疗。观察并记录两组治疗有效率,sICAM-1、MPO、可溶性P-选择素水平,心率及血压水平。结果治疗后研究组有效率高于对照组,差异有统计学意义(P <0.05);治疗前两组sICAM-1、MPO、可溶性P-选择素水平比较,差异无统计学意义(P> 0.05),治疗后两组sICAM-1、MPO、可溶性P-选择素水平低于治疗前,且观察组低于对照组,差异均有统计学意义(均P <0.05);治疗前两组心率及血压水平比较,差异无统计学意义(P> 0.05)。治疗后两组心率及血压水平低于治疗前,且研究组低于对照组,差异均有统计学意义(均P <0.05)。结论卡维地洛联合尼可地尔治疗老年冠心病心绞痛的有效率高,还可改善患者心室功能、心率、血压等情况。Objective To explore the effect of Carvedilol combined with Nicorandil in the treatment of elderly patients with coronary heart disease and angina pectoris and its effect on soluble intercellular adhesion molecule-1(sICAM-1)and myeloperoxidase(MPO)levels.Methods A total of 166 elderly patients with coronary heart disease and angina pectoris admitted to Beijing Huimin Hospital from January 2016 to January 2019 were selected as the subjects.According to the treatment regimen,the patients were divided into control group and study group,with 83 patients in each group.The control group was treated with Carvedilol,and the study group was treated with Nicordil based on the control group.sICAM-1,MPO,soluble P-selectin levels,heart rate and blood pressure in both groups were observed and recorded.Results After treatment,the effective rate of the study group was higher than that of the control group,and the difference was statistically significant(P<0.05).There were no statistically significant differences in the sICAM 1,MPO,soluble P-select element level between the two groups before treatment(P>0.05),after treatment sICAM-1,MPO,soluble P-level in the two groups were lower than those before treatment,those of the study group were lower than the control group,the differences were all statistically significant(all P<0.05).There were no statistically significant differences in heart rate and blood pressure between the two groups before treatment(P>0.05),after treatment,the heart rate and blood pressure of the two groups were lower than those before treatment,and those of the study group were lower than those of the control group,with statistically significant differences(all P<0.05).Conclusion Carvedilol combined with Nicorandil is effective in the treatment of angina pectoris in elderly patients with coronary heart disease,and it can also improve patients′ventricular function,heart rate,blood pressure and other conditions.

关 键 词：卡维地洛 尼可地尔 冠心病 心绞痛 可溶性细胞间黏附分子-1水平 髓过氧化物酶水平 

分 类 号：R54[医药卫生—心血管疾病]