368株临床常见病原菌的分布及其对抗菌药物的耐药性分析  

Analysis on Clinical Distribution and Antimicrobial Resistance of 368 Strains of Common Pathogens

作　　者：陈耀升 王娟[1] 张慧芝 CHEN Yao-sheng;WANG Juan;ZHANG Hui-zhi(Zhengzhou Hospital Affiliated to Ji'nan University(The No.2 People's Hospital of Zhengzhou},Zhangzhou 450000,China)

机构地区：[1]暨南大学附属郑州医院(郑州市第二人民医院),郑州450000

出　　处：《抗感染药学》2020年第6期809-812,共4页Anti-infection Pharmacy

摘　　要：目的:通过细菌耐药性监测,分析临床常见病原菌的分布及其对抗菌药物的耐药趋势,为临床合理选用抗菌药物提供理论依据。方法:收集2019年医院住院患者临床送检的各类标本2248份的细菌培养和药敏结果,分析其纸片扩散法(K-B法)和微量肉汤稀释法测定的最低抑菌浓度(MIC)和检出病原菌的临床分布及其耐药性。结果:收集的各类送检标本2248份中,检出病原菌368株,其中检出病原菌TOP 3为表皮葡萄球菌112株(占30.40%)、肺炎克雷伯菌46株(占12.50%)、铜绿假单胞菌39株(占10.60%);标本中检出病原菌TOP 3主要为眼分泌物(44.02%)、痰液(19.57%)和血液(14.95%);致病菌因抗菌药物的作用机制不同,其耐药性有很大差异。结论:加强对病原菌的耐药性监测,有利于临床按照药敏试验结果合理选用抗菌药物,以确保临床用药的有效性和安全性。Objective:To analyze the clinical distribution of common pathogenic bacteria and their antimicrobial resistance trend,and to monitor bacterial resistance,so as to provide theoretical basis for rational selection of antibiotics in clinic.Methods:The data of bacterial culture and drug sensitivity of 2248 specimens of various types submitted for clinical examination by hospitalized patients in 2019 were collected,and the minimum inhibitory concentration(MIC)determined by the strip diffusion method(K-B method)and the broth microdilution method,as well as the clinical distribution and drug resistance of pathogenic bacteria were analyzed.Results:Among the 2248 specimens collected,368 strains of pathogenic bacteria were detected,among which the TOP 3 strains were 112 strains of Staphylococcus epidermal(30.40%),46 strains of Klebsiella pneumoniae(12.50%)and 39 strains of Pseudomonas aeruginosa(10.60%).The TOP 3 pathogenic bacteria detected in the samples were mainly eye secretion(44.02%),sputum(19.57%)and blood(14.95%).The resistance of pathogenic bacteria varies greatly due to the different mechanisms of action of antimicrobial agents.Conclusion:Strengthening the monitoring of drug resistance of pathogenic bacteria is conducive to the rational selection of antimicrobial agents according to the results of drug sensitivity test,so as to ensure the effectiveness and safety of clinical drug use.

关 键 词：病原菌 药敏试验 合理用药 抗菌药物 耐药趋势 

分 类 号：R969.3[医药卫生—药理学] R915[医药卫生—药学]