粒细胞集落刺激因子对IVF-ET拮抗剂方案鲜胚移植妊娠结局的影响  

Effect of granulocyte colony stimulating factor on pregnancy outcome of fresh embryo transfer in IVF-ET cycles

作　　者：茹慧波 董九华 王琇 张亦心 杜丽荣 RU Hui-bo;DONG Jiu-hua;WANG Xiu;ZHANG Yi-xin;DU Li-rong(nnPHebei Research Institute for Family Planning/Key Laboratory for Family Planning & Healthy Birth,National Health & Family Planning Commission/Hebei Key Laboratory of Reproductive Medicine,Shijiazhuang 050071)

机构地区：[1]河北省计划生育科学技术研究院,国家卫生健康委员会计划生育与优生重点实验室,河北省生殖医学重点实验室,石家庄050071

出　　处：《生殖医学杂志》2020年第7期913-918,共6页Journal of Reproductive Medicine

基　　金：河北省科技厅科研基金资助项目(2020255)。

摘　　要：目的探讨粒细胞集落刺激因子(G-CSF)对IVF-ET拮抗剂方案鲜胚移植患者妊娠率的影响。方法2018年1月至2019年10月于我院采用拮抗剂方案行IVF-ET助孕的患者,随机分为G-CSF治疗组(n=41)和对照组(n=42),观察IVF-ET拮抗剂方案鲜胚移植后使用G-CSF对妊娠结局的影响。结果与对照组比较,G-CSF治疗组HCG阳性率(75.60%vs.47.61%)、临床妊娠率(63.41%vs.40.47%)、胚胎种植率(53.62%vs.35.71%)均显著升高(P<0.05)。结论G-CSF可提高IVF-ET拮抗剂方案鲜胚移植的妊娠率,其机制有待进一步研究。Objective:To investigate the effect of granulocyte colony stimulating factor(G-CSF)on pregnancy rate of fresh embryo transplant in IVF-ET cycles with antagonist protocol.Methods:The patients undergoing IVF-ET in our hospital from January 2018 to October 2019 and were randomly divided into G-CSF treatment group(n=41)and control group(n=42)to observe the effect of using G-CSF on pregnancy outcome after the fresh transplantation of IVF-ET with antagonistic scheme.Results:In Comparison with that in the control group,the HCG positive rate(75.60%vs.47.61%),clinical pregnancy rate(63.41%vs.40.47%),embryo implantation rate(53.62%vs.35.71%)in the G-CSF treatment group were significantly higher(P<0.05).Conclusions:G-CSF can improve the pregnancy outcome of fresh embryo transfer in IVF-ET cycles with antagonist protocol,and its mechanism needs further study.

关 键 词：粒细胞集落刺激因子 拮抗剂方案 新鲜移植 妊娠结局 

分 类 号：R711.6[医药卫生—妇产科学]