腹腔内脂多糖污染在子宫内膜异位症发生发展过程中的作用  

Role of lipopolysaccharide contamination in abdominal cavity in occurrence and development of endometriosis

作　　者：倪喆鑫 孙帅 程雯 俞超芹 NI Zhe-xin;SUN Shuai;CHENG Wen;YU Chao-qin(Department of TCM Gynecology,Changhai Hospital,the Second Military Medical University,Shanghai200433)

机构地区：[1]海军军医大学附属长海医院中医妇科,上海200433

出　　处：《生殖医学杂志》2020年第7期968-971,共4页Journal of Reproductive Medicine

基　　金：国家自然科学基金资助项目(81774352,81703874,81503604,81573755);上海市中医药三年行动计划[ZY(2018-2020)-FWTX-1107]。

摘　　要：经血逆流学说是目前最广为接受的子宫内膜异位症发病机制学说,但是与子宫内膜异位症实际发病率却不相符合。菌群微生态是近年来的研究热点。阴道菌群失调易位会导致脂多糖随逆流的经血进入女性腹腔,诱发腹腔内慢性低度炎症和免疫抑制环境,促进子宫内膜异位症的发生发展。基于此,本文通过综述现有脂多糖与子宫内膜异位症相关研究,进一步完善经血逆流学说。The theory of retrograde menstruation is the most widely accepted theory of endometriosis(EMs)pathogenesis,but it is not consistent with actual incidence of EMs.Microflora microecology is a research hotspot in recent years.The evidence shows that the dysfunctional translocation of vaginal flora will lead to lipopolysaccharide(LPS)flowing into the abdominal cavity of women with retrograde menstruation,which induce chronic low-grade inflammation and immunosuppressive environment in the abdominal cavity and promote the occurrence and development of EMs.Based on this,this paper further improved the theory of retrograde menstruation by reviewing the existing researches on LPS and EMs.

关 键 词：子宫内膜异位症 经血逆流 脂多糖 

分 类 号：R711.71[医药卫生—妇产科学]