Gd-EOB-DTPA增强MRI评估功能性肝体积与肝功能Child-Pugh分级的相关性  

The association between functional liver volume and liver function evaluated by quantitative analysis of gadoxetic acid-enhanced magnetic resonance imaging

作　　者：蔡佳乐 王兆洪[2] 陈辉[2] 童洪飞[2] CAI Jiale;WANG Zhaohong;CHEN Hui;TONG Hongfei(School of Nursing,Wenzhou Medical University,Wenzhou 325035,China;Department of Hepatobiliary Surgery,the Second Affiliated Hospital&Yuying Children’s Hospital of Wenzhou Medical University,Wenzhou 325027,China)

机构地区：[1]温州医科大学护理学院,浙江温州325035 [2]温州医科大学附属第二医院育英儿童医院肝胆外科,浙江温州325027

出　　处：《温州医科大学学报》2020年第8期637-641,共5页Journal of Wenzhou Medical University

基　　金：温州市公益性科技计划项目(Y20160143);浙江省自然科学基金资助项目(LY19H290009)。

摘　　要：目的:对比解剖性肝脏体积(ALV)和功能性肝脏体积(FLV)与肝功能Child-Pugh分级的相关性。方法:选择温州医科大学附属第二医院育英儿童医院2014年1月至2019年4月同时行增强CT和Gd-EOB-DTPA增强MRI扫描的肝硬化患者25例。对所有患者进行肝功能Child-Pugh评分,检测所有入组患者每个肝段的Gd-EOB-DTPA增强MRI平扫期和肝胆特异期的信号对比增强率(CER),以CT扫描的数据为基础利用MI-3DVS计算每个肝段的ALV和全肝的FLV。分析ALV和FLV与肝功能Child-Pugh分级的相关性。结果:肝功能ChildPugh分级与ALV呈负相关(r=-0.792,P<0.001),曲线拟合的决定系数(R^2)=0.63;肝功能Child-Pugh分级与FLV亦呈负相关(r=-0.911,P<0.001),曲线拟合的R^2=0.80。FLV与肝功能Child-Pugh分级有更显著的负相关性。结论:结合Gd-EOB-DTPA增强MRI平扫期和肝胆特异期的信号CER和ALV计算所得的FLV较ALV能更好地反映肝脏的功能状态。Objective:To compare correlations between FLV and Child-Pugh classification of liver function.Methods:All 25 patients with liver cirrhosis performed enhanced CT and Gd-EOB-DTPA-enhanced MRI were recruited in this study.The liver function of all cases was evaluated by Child-Pugh classification.The contrast enhancement ratio(CER)was analyzed by SIlh-SIlu/SIlu,and the volume of each liver segment measured by MI-3DVS.Then correlations between anatomical liver volume,functional liver volume and Child-Pugh classification of liver function analyzed.Results:Analyses showed that Child-Pugh classification of liver function was negatively correlated to the ALV(r=-0.792,P<0.001),with determination coefficient of curve fitting(R^2=0.63);Child-Pugh classification of liver function was also negatively correlated with FLV(r=-0.911,P<0.001),determination coefficient of curve fitting(R^2=0.80).Compared between the two analyzing methods of liver volume,FLV had more significant negative correlation with Child-Pugh classification of liver function.Conclusion:The FLV calculated by CER of Gd-EOB-DTPA-enhanced MRI combined with ALV from MI-3DVS could better reflect the liver function than ALV.

关 键 词：肝功能 功能性肝体积 解剖性肝体积 钆塞酸二钠增强磁共振 三维重建 

分 类 号：R445.2[医药卫生—影像医学与核医学]