钯催化3,4-二氢嘧啶-2-硫酮C2位功能化衍生物的合成  

The synthesis of 3,4-dihydropyrimidine-2-thiones C2 functionalized derivatives through palladium-catalyzed

作　　者：王喜存[1] 陈辉 朱政和 WANG Xi-cun;CHEN Hui;ZHU Zheng-he(College of Chemistry and Chemical Engineering,Northwest Normal University,Lanzhou 730070,Gansu,China)

机构地区：[1]西北师范大学化学化工学院,甘肃兰州730070

出　　处：《西北师范大学学报（自然科学版）》2020年第4期62-70,共9页Journal of Northwest Normal University(Natural Science)

基　　金：国家自然科学基金资助项目(21362031,21562036)。

摘　　要：在钯催化下,3,4-二氢嘧啶-2-硫酮(DHPMs)与芳基磺酰肼发生脱硫偶联反应制备了一系列2-芳基嘧啶类化合物.通过1HNMR和13CNMR对目标化合物的结构进行了表征.结果表明,该方法以芳基磺酰肼为芳基源,具有操作简单、底物范围广、官能团耐受性好等优点,是一种合成2-芳基嘧啶类化合物简单有效的策略.A series of 2-arylpyrimidine derivatives were prepared by desulfurization coupling reaction of 3,4-dihydropyrimidine-2-thiones(DHPMs)and arylsulfonyl hydrazides under palladium-catalyzed.The structures of 2-arylpyrimidine derivatives were characterized by 1HNMR and 13CNMR spectrum.There are some advantages of this method,such as simple operation,wide scope of substrates and good functional group tolerance.It provides a simple and effective method for the synthesis of 2-arylpyrimidine derivatives.

关 键 词：3 4-二氢嘧啶-2-硫酮 芳基磺酰肼 C—S键断裂 2-芳基嘧啶 

分 类 号：O626.32[理学—有机化学]