血清TNF-α、IGF-1在过敏性紫癜及紫癜性肾炎患儿检测中的临床意义  

Clinical Significance on the Detection of Serum TNF-αand IGF-1 in the Children with Henoch-schonlein Purpura and Henochschonlein Purpura Nephritis

作　　者：吴挺柏[1] 王婷[1] 阮静维 郑铠军[1] WU Ting-bai;WANG Ting;RUAN Jing-wei;ZHENG Kai-jun(People's Hospital of Zhongshan City,Zhongshan 528400,China)

机构地区：[1]中山市人民医院,广东中山528400

出　　处：《中国医药指南》2020年第19期1-3,共3页Guide of China Medicine

基　　金：中山市科技计划项目,血清TNF-α,IGF-1在过敏性紫癜及紫癜性肾炎患儿检测中的临床意义,2019SYF05。

摘　　要：目的回顾性研究血清TNF-α、IGF-1联合检测在过敏性紫癜及后继紫癜性肾炎患儿中表达差异的临床意义。方法选取2016年1月至2020年2月期间的80例初发过敏性紫癜患儿为研究对象,将其根据治疗6个月后的情况分为A组(紫癜性肾炎组)43例和B组(过敏性紫癜组)37例,选取同时期的20名健康儿童为C组。检测与比较三组的血清TNF-α及IGF-1水平,并比较A组与B组中缓解期及发作期的检测结果,比较A组中不同病理分级者的检测结果,采用直线相关分析处理紫癜性肾炎患儿血清TNF-α与IGF-1的关系,并采用Spearman秩相关分析血清TNF-α、IGF-1与紫癜性肾炎病理分级的关系。结果A组的血清TNF-α及IGF-1水平显著高于B组及C组,B组则显著高于C组,A组与B组中发作期的检测结果显著高于缓解期,且A组中不同病理分级者的检测结果比较,差异有统计学意义(P<0.05),直线相关分析显示,紫癜性肾炎患儿血清TNF-α与IGF-1存在正相关(P<0.05),Spearman秩相关分析显示,血清TNF-α、IGF-1与紫癜性肾炎病理分级的关系呈正相关(P<0.05)。结论检测血清TNF-α、IGF-1在过敏性紫癜及后继紫癜性肾炎两阶段的不同表达差异,对于揭示该类疾病的不同阶段表现和分期依据以及病理分级预测具有较高的检测价值。Objective The clinical significance of serum TNF-αand IGF-1 in children with Henoch Schonlein purpura and subsequent purpura nephritis was studied retrospectively.Methods 80 children with henoch-schonlein purpura from January 2016 to February 2020 were chosen as the study object,and they were divided into group A(henoch-schonlein purpura group)43 cases and group B(henoch-schonlein purpura nephritis group)37 cases according to treatment situation at 6th month after the treatment,20 healthy children at the same time were chosen as group C.Then the serum TNF-αand IGF-1 of three group were detected and compared,and the detection results of group A and group B at remission period and attack period were compared,the detection results of group A with different pathological grades were compared too,then the relationship between serum TNF-α,IGF-1 and henoch-schonlein purpura nephritis were analyzed with linear correlation analysis,the relationship between serum TNF-α,IGF-1 and pathological grades of henoch-schonlein purpura nephritis were analyzed with Spearman rank correlation analysis.Results The serum TNF-αand IGF-1 of group A were significantly higher than the levels of group B and group C,the results of group B were significantly higher than those of group C,the detection results of group A and group B at attack period were significantly higher than those at remission period,the detection results of group A with different pathological grades were compared,there were statistically significant differences(P<0.05),the linear correlation analysis showed the serum TNF-αwas positively correlated with serum IGF-1 of children with henoch-schonlein purpura nephritis(P<0.05),the Spearman rank correlation analysis showed the serum TNF-αand IGF-1 were positively correlated with pathological grades of henoch-schonlein purpura nephritis(P<0.05).Conclusion Detection of serum TNF-αand IGF-1 expression difference in the two stages of Henoch Schonlein purpura and subsequent purpura nephritis has a high detection value for reve

关 键 词：血清 TNF-α IGF-1 过敏性紫癜 紫癜性肾炎 患儿 

分 类 号：R692.34[医药卫生—泌尿科学]