补阳还五汤配合三仁汤治疗脾肾亏虚兼湿热瘀血型早期糖尿病肾病的临床药理研究  

Clinical Pharmacological Study of Buyang Huanwu Decoction Combined with Sanren Decoction in the Treatment of Early Diabetic Nephropathy with Deficiency of Spleen and Kidney and Blood Stasis of Damp heat

作　　者：郭菲[1] 贾曼[1] GUO Fei;JIA Man(Liaocheng People's Hospital,Liaocheng 252000,China)

机构地区：[1]聊城市人民医院,山东聊城252000

出　　处：《中国医药指南》2020年第19期18-20,共3页Guide of China Medicine

摘　　要：目的探讨补阳还五汤合三仁汤加减治疗早期糖尿病肾病脾肾亏虚兼湿热瘀血证的临床效果。方法选取我院(2017年7月至2020年1月)收治的90例DN患者,根据不同治疗分为2组,对照组(n=45)接受常规治疗,观察组(n=45)接受补阳还五汤合三仁汤加减治疗,对比两组患者临床疗效和血糖水平、血脂水平、氧化应激指标、炎性因子指标及临床疗效。结果观察组临床总有效率88.89%(40/45),对照组临床总有效率62.22%(28/45),两组患者临床疗效对比差异明显,观察组显著优于对照组(χ~2=19.2559,P<0.05)。观察组HbA1c(6.23±0.24)%、FBG(6.23±0.74)mmol/L、2h BG(7.75±1.27)mmol/L、HDL-C(1.52±0.38)mmol/L、LDL-C(2.25±0.14)mmol/L、TG(1.27±0.46)mmol/L、TC(2.87±0.79)mmol/L,对照组HbA1c(6.62±0.75)%、FBG(6.92±1.10)mmol/L、2h BG(9.23±1.64)mmol/L、HDL-C(1.19±0.30)mmol/L、LDL-C(3.15±0.61)mmol/L、TG(2.34±1.15)mmol/L、TC(5.34±1.25)mmol/L,两组患者血糖和血脂水平对比差异明显(t=3.3223、3.4914、4.7864、4.5724、9.6565、5.7951、11.2052,P<0.05)。观察组GSH-Px(139.67±17.64)U/mL、SOD(96.49±8.51)U/mL、MDA(5.47±1.07)μmol/L、TNF-α(14.46±2.70)ng/mL、IL-2(11.35±2.07)ng/mL、IL-4(48.52±5.47)ng/mL、IL-8(16.95±2.36)ng/mL、IL-10(69.55±8.61)ng/mL,对照组GSH-Px(110.56±14.17)U/mL、SOD(82.76±6.42)U/mL、MDA(9.23±1.62)μmol/L、TNF-α(24.67±3.14)ng/mL、IL-2(19.63±2.53)ng/mL、IL-4(33.29±3.71)ng/mL、IL-8(32.69±4.65)ng/mL、IL-10(50.63±6.47)ng/mL,两组患者氧化应激和炎性因子指标对比差异明显(t=8.6304、8.6401、12.9916、16.5388、16.9916、15.4575、20.2483、11.7845,P<0.05)。两组患者均没有出现严重不良反应。结论补阳还五汤合三仁汤加减治疗早期糖尿病肾病脾肾亏虚兼湿热瘀血证的临床效果满意,安全性较高,值得临床推广使用。Objective To explore the clinical effect of Buyang Huanwu Decoction and Sanren Decoction in the treatment of early diabetic nephropathy with spleen kidney deficiency and damp heat blood stasis.Methods 90 patients with DN admitted to our hospital(July 2017-January 2020)were divided into two groups according to different treatment.The control group(n=45)received routine treatment,and the observation group(n=45)received Buyang Huanwu Decoction and Sanren Decoction plus and minus treatment.The clinical effect,blood glucose level,blood lipid level,oxidative stress index,inflammatory factor index and clinical effect of the two groups were compared.Results The total clinical effective rate of the observation group was 88.89%(40/45),and the total clinical effective rate of the control group was 62.22%(28/45).The difference between the two groups was significant,and the observation group was significantly better than the control group(χ2=19.2559,P<0.05).Observation group HbA1c(6.23±0.24)%,FBG(6.23±0.74)mmol/L,2hBG(7.75±1.27)mmol/L,HDL-C(1.52±0.38)mmol/L,LDL-C(2.25±0.14)mmol/L,TG(1.27±0.46)mmol/L,TC(2.87±0.79)mmol/L,control group HbA1c(6.62±0.75)%,FBG(6.92±1.10)mmol/L,2hBG(9.23±1.64)mmol/L,HDL-C(1.19±0.30)mmol/L,LDL-C(3.15±0.61)mmol/L,TG(2.34±1.15)mmol/L,TC(5.34±1.25)mmol/L,two groups The differences in blood glucose and blood lipid levels were significant(t=3.3223,3.4914,4.7864,4.5724,9.6565,5.7951,11.2052,P<0.05).Observation group GSH-Px(139.67±17.64)U/mL,SOD(96.49±8.51)U/mL,MDA(5.47±1.07)μmol/L,TNF-α(14.46±2.70)ng/mL,IL-2(11.35±2.07)ng/mL,IL-4(48.52±5.47)ng/mL,IL-8(16.95±2.36)ng/mL,IL-10(69.55±8.61)ng/mL,control group GSH-Px(110.56±14.17)U/mL,SOD(82.76±6.42)U/mL,MDA(9.23±1.62)μmol/L,TNF-α(24.67±3.14)ng/mL,IL-2(19.63±2.53)ng/mL,IL-4(33.29±3.71)ng/mL,IL-8(32.69±4.65)ng/mL,IL-10(50.63±6.47)ng/mL,differences in oxidative stress and inflammation factors between the two groups Obvious(t=8.6304,8.6401,12.9916,16.5388,16.9916,15.4575,20.2483,11.7845,P<0.05).There were no serious adverse reacti

关 键 词：补阳还五汤 三仁汤 早期糖尿病肾病 脾肾亏虚 湿热瘀血 

分 类 号：R587.2[医药卫生—内分泌]