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作 者:兀江波 杨创杰 叶勇[3] WU Jiang-bo;YANG Chuang-jie;YE Yong(Department of Pharmacy,Sanmenxia Hospital of Traditional Chinese Medicine,Sanmenxia Henan 472000,China;Department of Laboratory,Sanmenxia Hospital of Traditional Chinese Medicine,Sanmenxia Henan 472000,China;Intensive Care Unit,Fujian Provncial Cancer Hospital,Fuzhou Fujian 350014,China)
机构地区:[1]三门峡市中医院药剂科,河南三门峡472000 [2]三门峡市中医院检验科,河南三门峡472000 [3]福建医科大学附属省肿瘤医院重症医学科,福建福州350014
出 处:《药品评价》2020年第5期12-14,共3页Drug Evaluation
摘 要:目的:探讨降钙素原(PCT)、血清淀粉样蛋白A(SAA)及肝素结合蛋白(HBP)检测在重症医学科(ICU)感染患者中的应用价值。方法:选取2017年4月至2018年5月我院收治的83例ICU感染患者为研究对象,根据病原学检查结果将其分为细菌感染组(n=45)和非细菌感染组(n=38),并选取同期40名体检健康者为健康对照组。比较各组PCT、SAA、HBP及白细胞(WBC)水平,采用受试者工作特征曲线(ROC)下面积(AUC)评价PCT、SAA及HBP水平单独及联合检测在细菌感染组与非细菌感染组中的诊断价值。结果:细菌感染组和非细菌感染组PCT、SAA、HBP及WBC水平明显高于健康对照组(P<0.05),细菌感染组PCT、SAA及HBP水平明显高于非细菌感染组(P<0.05),细菌感染组和非细菌感染组WBC水平比较差异无统计学意义(P>0.05);PCT、SAA及HBP水平单独及联合检测细菌感染组与非细菌感染组的AUC值分别为0.864、0.909、0.799及0.956,PCT、SAA及HBP联合检测的AUC值明显高于各项指标单独检测的AUC值(P<0.05)。结论:PCT、SAA及HBP检测在ICU感染的诊断中具有重要价值,PCT、SAA及HBP联合检测的灵敏度及特异度高,可作为ICU感染的诊断指标。Objective:To investigate the application value of procaleitonin(PCT),serum amyloid A(SAA)and heparin binding protein(HBP)in patients with infection in intensive care unit(ICU).Methods:A total of 83 cases of ICU infection patients treated in our hospital from Apr.2017 to May.2018 were selected,and they were divided into bacterial infection group(n=45)and non-bacterial infection group(n=38)according to the results of pathogenic examination,and 40 cases of healthy people were selected as healthy control group in the same period.The levels of PCT,SAA,HBP and white blood cells(WBC)in each group were compared,and the diagnostic value of PCT,SAA and HBP levels alone and jointly in bacterial infection group and non-bacterial infection group was evaluated by using the area under(AUC)the receiver operating characteristic(ROC)curve.Results:The levels of PCT,SAA,HBP and WBC in bacterial infection group and non-bacterial infection group were significantly higher than those of healthy control group(P<0.05),the levels of PCT,SAA and HBP in bacterial infection group were significantly higher than those of non-bacterial infection group(P<0.05),and there was no significant difference in WBC level between the bacterial infection group and non-bacterial infection group(P>0.05);The AUC values of PCT,SAA and HBP levels were detected separately and jointly in bacterial infection group and non-bacterial infection group were 0.864,0.909,0.799 and 0.956,respectively,and the AUC value of the combined detection of PCT,SAA and HBP levels was significantly higher than that of the AUC value of various indicators obtained by a single measurement(P<0.05).Conclusion:The detection of PCT,SAA and HBP has important value in the diagnosis of ICU infection,and the combined detection of PCT,SAA and HBP has high sensitive and specific,which can be used as the diagnostic index for bacterial infection in ICU patients.
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