温针灸治疗风寒型面神经麻痹的疗效及对GDNF和NGF表达水平的影响  

Effect of Needle-Warming Moxibustion on Expressions of GDNF and NGF in Treating Facial Paralysis of Wind-Cold Pattern

作　　者：赵婧 许晓爽 鄢燕 ZHAO Jing;XU Xiaoshuang;YAN Yan(Xiangyang Hospital of TCM, Xiangyang 441000, China)

机构地区：[1]襄阳市中医医院,湖北襄阳441000

出　　处：《针灸临床杂志》2020年第6期19-23,共5页Journal of Clinical Acupuncture and Moxibustion

基　　金：湖北省卫生健康委员会项目,编号:WJ2019F090。

摘　　要：目的:观察温针灸治疗风寒型面神经麻痹的疗效及对患者胶质细胞系来源的神经营养因子(GDNF)、神经生长因子(NGF)表达水平的影响。方法:选取我院2017年3月—2018年3月收治的风寒型面神经麻痹患者112例,随机分为对照组56例与观察组56例。在常规西药治疗基础上,对照组采取基础针刺治疗,观察组在对照组基础上联合温针灸治疗。比较两组面神经肌电图、面神经功能评分、面神经功能缺损程度、临床疗效、GDNF和NGF水平、不良反应、中医症候积分变化。结果:治疗后,观察组潜伏期小于对照组(P<0.05),波幅大于对照组(P<0.05),H-B评分低于对照组(P<0.05),Portmann评分高于对照组(P<0.05),观察组中医症候积分显著低于对照组(P<0.05);观察组临床总有效率94.64%(53/56)显著高于对照组82.14%(46/56)(P<0.05);治疗后观察组GDNF、NGF水平均显著高于对照组(P<0.05);对照组不良反应发生率8.93%(5/56)略高于观察组7.14%(4/56),但比较差异无统计学意义(P>0.05)。结论:温针灸治疗风寒型面神经麻痹能显著改善患者面神经功能,上调GDNF、NGF水平,提高临床疗效,安全性较高,值得推广。Objective:To investigate the effect of needle-warming moxibustion on the expressions of glial cell line-derived neurotrophic factor(GDNF)and nerve growth factor(NGF)in patients with facial paralysis of wind-cold pattern.Methods:112 cases of cold type facial paralysis were randomly divided into the control group(n=56)and the observation group(n=56).Both groups received the routine western medication.The control group was also treated with acupuncture;on which basis,the observation group was treated with needle-warming moxibustion.The facial nerve electromyogram,the scores of facial nerve function,the impairment degree of facial nerve function,the clinical effect,the levels of GDNF and NGF,the adverse reactions and TCM syndrome scores were compared between the two groups after the treatment.Results:The lantency was shorter and H-B scores were lower,longer amplitude was longer and Portmann scores were higher in the observation group than those in the control group after the treatment(P<0.05).The TCM syndrome score of the observation group was significantly lower than that of the control group(P<0.05).The total clinical effective rate was 94.64%(53/56)in the observation group,which was significantly higher than 82.14%(46/56)in the control group(P<0.05).The levels of GDNF and NGF were significantly higher in the observation group than those in the control group after the treatment(P<0.05).The incidence of adverse reactions in the control group was 8.93%(5/56),which was slightly higher than 7.14%(4/56)in the observation group,which showed no statistic difference(P>0.05).Conclusion:Needle-warming moxibustion can effectively and safely improve the facial nerve function,and up-regulate the levels of GDNF and NGF in patients with facial paralysis of wind-cold pattern.The therapy is worthy of promotion.

关 键 词：针刺 温针灸 风寒型 面神经麻痹 胶质细胞源性神经营养因子 神经生长因子 

分 类 号：R246.6[医药卫生—针灸推拿学]