中药黄酮类化合物治疗糖尿病肾病的研究现状  

Research status of the treatment of diabetic nephropathy with flavonoids

作　　者：顾丽媛 唐海涛 孙云[1] 许正新[1] GU Li-yuan;TANG Hai-tao;SUN Yun;XU Zheng-xin(School of Medicine,Yangzhou University,Yangzhou 225001,Jiangsu Province,China;Suzhong Huangkui Research Institute,Taizhou 225300,Jiangsu Province,China)

机构地区：[1]扬州大学医学院,江苏扬州225001 [2]苏中黄葵研究院,江苏泰州225300

出　　处：《中国临床药理学杂志》2020年第12期1729-1732,共4页The Chinese Journal of Clinical Pharmacology

基　　金：国家重大新药创新基金资助项目(2013ZX09104003)。

摘　　要：糖尿病肾病(diabetic nephropathy,DN)是糖尿病并发症之一。目前,临床上缺乏可有效治疗DN的药物,运用中药治疗DN的研究报道亦罕见。通过对国内外相关文献所涉及的中药成分归类及分析发现含有黄酮类化合物的中药在DN治疗方面效果显著。为深入评价该类成分在治疗DN中的功效,本文从DN研究现状,治疗DN药物的作用及其机制,以及中西药联合应用治疗DN可以产生协同作用、拮抗药物不良反应,减少用量等方面进行综述,为今后高效、安全的DN治疗药物研发提供依据。Diabetic nephropathy(DN)is one of the complications of diabetes.At present,there is a lack of effective drugs for the treatment of DN clinically,and studies on the treatment of DN with traditional Chinese medicine are also rare.Through the classification and analysis of traditional Chinese medicine components involved in relevant literatures at home and abroad,it is found that traditional Chinese medicine containing flavonoids has a significant effect on DN treatment.For further evaluation of the efficacy in the treatment of DN,this article reviews the current situation of DN research,the role and mechanism of DN drugs,and the synergistic effect of Chinese and Western drugs in the treatment of DN,as well as the adverse drug reactions and dosage reduction,so as to provide a basis for the development of efficient and safe DN treatment in the future.

关 键 词：黄酮类化合物 糖尿病肾病 中西药物合用 协同作用 

分 类 号：R28[医药卫生—中药学]