金黄色葡萄球菌临床感染分布及耐药性变迁的探讨  

Discussion on clinical infection distribution and drug resistance change of Staphylococcus aureus

作　　者：徐晨蕾 郑琳[1] 赵枫[1] XU Chen-lei;ZHENG Lin;ZHAO Feng(Center for Laboratory Medicine,the Affiliated Hospital of Medical College,Ningbo University,Ningbo,Zhejiang 315020,China)

机构地区：[1]宁波大学医学院附属医院检验医学中心,浙江宁波315020

出　　处：《中国卫生检验杂志》2020年第12期1447-1449,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的了解宁波大学医学院附属医院2016年-2018年金黄色葡萄球菌的临床分布特点、对抗菌药物的耐药特征及耐甲氧西林金黄色葡萄球菌(MRSA)检出情况,为临床合理地使用抗菌药物提供依据。方法采用VITEK 2 Compact全自动细菌检测分析系统对临床分离的金黄色葡萄球菌进行细菌鉴定及药敏试验。采用WHONET 5.4和SPSS 18.0软件对金黄色葡萄球菌的临床分布、标本来源以及耐药率等进行统计分析。结果共分离到金黄色葡萄球菌751株,其中痰液标本检出率最高,占56.99%,检出率最高的科室是小儿内科,占25.43%;共检出301株MRSA,检出率为40.08%。3年来分离的金黄色葡萄球菌对青霉素G、红霉素、克林霉素、苯唑西林均具有较高的耐药性。结论本院检出的金黄色葡萄球菌对多种抗菌药物可产生不同程度的耐药性,且MRSA的耐药性日趋严重,应加强预防和控制院内感染,规范临床合理使用抗菌药物。Objective To investigate the clinical distribution characteristics of Staphylococcus aureus from 2016 to 2018 in the Affiliated Hospital of Medical School of Ningbo University,the resistance characteristics of antibiotics and the detection of methicillin-resistant Staphylococcus aureus(MRSA),to provide reference for clinical rational use of antibiotics.Methods Bacterial identification and drug susceptibility testing of clinically isolated Staphylococcus aureus were carried out by using VITEK 2 Compact automatic bacterial detection and analysis system.The clinical distribution,specimen source and drug resistance rate of Staphylococcus aureus were statistically analyzed using WHONET 5.4 and SPSS 18.0 software.Results A total of 751 strains of Staphylococcus aureus were isolated,among which the detection rate of sputum samples was the highest,accounting for 56.99%;the highest detection rate in Staphylococcus aureus is pediatric medicine,accounting for 25.43%;a total of 301 MRSA were detected,and the detection rate was 40.08%.Staphylococcus aureus isolated in the past three years has high resistance to penicillin G,erythromycin,clindamycin and oxacillin.Conclusion The Staphylococcus aureus detected in our hospital can produce different degrees of resistance to various antibacterial drugs,and the resistance of MRSA is becoming more and more serious.It is necessary to strengthen prevention and control of nosocomial infections and standardize clinical rational use of antibacterial drugs.

关 键 词：金黄色葡萄球菌 临床分布 耐药性 

分 类 号：R446.5[医药卫生—诊断学]